Apalutamide Dosage

Medically reviewed by Drugs.com. Last updated on Sep 8, 2023.

Usual Adult Dose for Prostate Cancer

240 mg orally once a day

Comments:

• Patients should receive a gonadotropin-releasing hormone (GnRH) analog concurrently or have had a bilateral orchiectomy.

Uses:

• For the treatment of metastatic castration-sensitive prostate cancer (mCSPC)
• For the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC)

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment required.
Severe or end-stage renal impairment: Data not available

Liver Dose Adjustments

Mild (Child-Pugh A) or moderate (Child-Pugh) hepatic impairment: No adjustment recommended.
Severe (Child-Pugh C) hepatic impairment: Data not available

Dose Adjustments

If a patient experiences a Grade 3 or greater toxicity or an intolerable side effect, hold dosing until symptoms improve to Grade 1 or less or original grade, then resume at the same dose or a reduced dose (180 mg or 120 mg).

Precautions

CONTRAINDICATIONS:

• None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Swallow tablets whole.
• May be taken with or without food.
• Take at the same time each day.
• If a dose is missed, take the normal dose as soon as possible on the same day and return to normal schedule the following day; extra tablets to make up the missed dose should not be taken.

Storage requirements:

• Store in original package.
• Do not discard desiccant.
• Protect from light and moisture.

Patient advice:

• Inform your healthcare provider if you develop a rash.
• Immediately contact your healthcare provider if you experience a seizure; engaging in any activity where sudden loss of consciousness could cause serious harm to yourself or others due the risk of seizures.
• This drug can be harmful to a developing fetus; if having sex with female partners of reproductive potential, use effective contraception during treatment and for 3 months after the last dose; use a condom if having sex with a pregnant woman.
• Do not donate sperm during therapy and for 3 months after the last done; this drug may impair male fertility.

Frequently asked questions

• How long do you have to take Erleada (apalutamide) for?
• How effective is Erleada (apalutamide)?
• What type of prostate cancer is Erleada used to treat?

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer