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Apalutamide Dosage

Medically reviewed by Drugs.com. Last updated on Jan 21, 2021.

Applies to the following strengths: 60 mg

Usual Adult Dose for:

Prostate Cancer

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Prostate Cancer

240 mg orally once a day

Comments:
-Patients should receive a gonadotropin-releasing hormone (GnRH) analog concurrently or have had a bilateral orchiectomy.

Uses:
-For the treatment of metastatic castration-sensitive prostate cancer (mCSPC)
-For the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC)

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment required.
Severe or end-stage renal impairment: Data not available

Liver Dose Adjustments

Mild (Child-Pugh A) or moderate (Child-Pugh) hepatic impairment: No adjustment recommended.
Severe (Child-Pugh C) hepatic impairment: Data not available

Dose Adjustments

If a patient experiences a Grade 3 or greater toxicity or an intolerable side effect, hold dosing until symptoms improve to Grade 1 or less or original grade, then resume at the same dose or a reduced dose (180 mg or 120 mg).

Precautions

CONTRAINDICATIONS:
-None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Swallow tablets whole.
-May be taken with or without food.
-Take at the same time each day.
-If a dose is missed, take the normal dose as soon as possible on the same day and return to normal schedule the following day; extra tablets to make up the missed dose should not be taken.

Storage requirements:
-Store in original package.
-Do not discard desiccant.
-Protect from light and moisture.

Patient advice:
-Inform your healthcare provider if you develop a rash.
-Immediately contact your healthcare provider if you experience a seizure; engaging in any activity where sudden loss of consciousness could cause serious harm to yourself or others due the risk of seizures.
-This drug can be harmful to a developing fetus; if having sex with female partners of reproductive potential, use effective contraception during treatment and for 3 months after the last dose; use a condom if having sex with a pregnant woman.
-Do not donate sperm during therapy and for 3 months after the last done; this drug may impair male fertility.