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Aggrenox Side Effects

Generic Name: aspirin / dipyridamole

Note: This page contains information about the side effects of aspirin / dipyridamole. Some of the dosage forms included on this document may not apply to the brand name Aggrenox.

In Summary

Common side effects of Aggrenox include: headache, diarrhea, and abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to aspirin / dipyridamole: oral capsule, oral capsule extended release

In addition to its needed effects, some unwanted effects may be caused by aspirin / dipyridamole. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking aspirin / dipyridamole:

More common:
  • Abdominal or stomach pain
  • vomiting
Less common:
  • Bleeding from the rectum
  • bloody mucous or unexplained nosebleeds
  • bloody or black, tarry stools
  • confusion
  • convulsions (seizures)
  • difficulty with breathing
  • difficulty with speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • memory loss
  • pale skin
  • purple or red spots on skin
  • slow speech
  • tightness in the chest
  • troubled breathing (exertional)
  • unusual bleeding or bruising
  • vomiting of blood or material that looks like coffee grounds
Rare
  • Abdominal or stomach fullness
  • blood in the urine
  • chills
  • clay-colored stools
  • collection of blood under the skin
  • cough
  • deep, dark purple bruise
  • gaseous abdominal or stomach pain
  • itching, pain, redness, or swelling of the eye or eyelid
  • loss of appetite
  • nausea
  • noisy breathing
  • recurrent fever
  • skin rash or hives (severe)
  • watering of the eyes
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking aspirin / dipyridamole, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • flushes
  • hearing loss
  • restlessness
  • sweating
  • unusual tiredness or weakness
  • warm feeling

Minor Side Effects

Some of the side effects that can occur with aspirin / dipyridamole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • belching
  • diarrhea
  • difficulty with moving
  • headache
  • heartburn
  • indigestion
  • muscle pain or stiffness
  • pain, swelling, or redness in the joints
  • stomach discomfort or upset
Less common or rare:
  • Back pain
  • burning feeling in the chest or stomach
  • loss of strength or energy
  • rectal pain or swelling
  • sleepiness or unusual drowsiness
  • taste loss
  • tenderness in the stomach area

For Healthcare Professionals

Applies to aspirin / dipyridamole: oral capsule extended release

General

The most common adverse reactions were headache, dizziness, dyspepsia, abdominal pain, nausea, and diarrhea.[Ref]

Nervous system

Very common (10% or more): Headache (39%), dizziness (up to 29.5%)
Common (1% to 10%): Convulsions, syncope, amnesia, somnolence, intracranial hemorrhage
Frequency not reported: Coma, paresthesia, cerebral hemorrhage, subarachnoid hemorrhage, tinnitus, taste loss
Postmarketing reports: Cerebral edema, migraine

Aspirin:
Very common (10% or more): Headache (34%), dizziness (29.2%)
Common (1% to 10%): Convulsions, syncope, amnesia, somnolence
Frequency not reported: Brain edema, lethargy, tinnitus

Dipyridamole:
Very common (10% or more): Headache (38%), dizziness (30.1%)
Common (1% to 10%): Convulsions, syncope, amnesia, somnolence[Ref]

Gastrointestinal

Very common (10% or more): Dyspepsia (18%), abdominal pain (18%), nausea (16%), diarrhea (13%)
Common (1% to 10%): Vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage
Frequency not reported: Gastritis, ulceration, perforation, gingival bleeding
Postmarketing reports: Pancreatitis, hematemesis

Aspirin:
Very common (10% or more): Dyspepsia (18%), abdominal pain (16%), nausea (13%)
Common (1% to 10%): Diarrhea, vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage
Frequency not reported: Gingival bleeding, gastric ulcer perforation, duodenal ulcer perforation, melena, hematemesis, pancreatitis

Dipyridamole:
Very common (10% or more): Dyspepsia (17%), diarrhea (16%), abdominal pain (15%), nausea (15%)
Common (1% to 10%): Vomiting, rectum hemorrhage, melena, hemorrhoids, gastrointestinal hemorrhage[Ref]

Other

Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia
Frequency not reported: Fever, deafness
Postmarketing reports: Hypothermia, chest pain, hearing loss, prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum bleeding, postpartum bleeding

Aspirin:
Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia
Frequency not reported: Deafness, prolonged pregnancy, prolonged labor, stillbirth, lower birth weight infants, antepartum hemorrhage, postpartum hemorrhage, pyrexia, hypothermia

Dipyridamole:
Common (1% to 10%): Pain, fatigue, accidental injury, malaise, asthenia[Ref]

Respiratory

Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis
Frequency not reported: Hyperpnea, asthma, bronchospasm, hemoptysis, pulmonary edema
Postmarketing reports: Respiratory alkalosis, laryngeal edema, tachypnea, dyspnea

Aspirin:
Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis
Frequency not reported: Dyspnea, laryngeal edema, hyperventilation, pulmonary edema, tachypnea

Dipyridamole:
Common (1% to 10%): Coughing, upper respiratory tract infection, epistaxis[Ref]

Hematologic

Common (1% to 10%): Hemorrhage not otherwise specified, anemia, major bleeding
Frequency not reported: Hematoma, hemoglobin decreased, hematocrit decreased, erythrocyte count decreased
Postmarketing reports: Prolongation of prothrombin time, disseminated intravascular coagulation, coagulopathy, thrombocytopenia, aplastic anemia, pancytopenia, thrombocytosis

Aspirin:
Common (1% to 10%): Hemorrhage not otherwise specified, anemia
Frequency not reported: Disseminated intravascular coagulation, coagulopathy

Dipyridamole:
Common (1% to 10%): Hemorrhage not otherwise specified, anemia[Ref]

Cardiovascular

Common (1% to 10%): Cardiac failure
Frequency not reported: Hypotension, tachycardia, palpitation, arrhythmia, supraventricular tachycardia, flushing
Postmarketing reports: Angina pectoris

Aspirin:
Common (1% to 10%): Cardiac failure
Frequency not reported: Arrhythmia

Dipyridamole:
Common (1% to 10%): Cardiac failure[Ref]

Dermatologic

Common (1% to 10%): Purpura
Frequency not reported: Pruritus, urticaria
Postmarketing reports: Rash, alopecia, angioedema, Stevens-Johnson syndrome, skin hemorrhages, bruising, ecchymosis, hematoma, allergic vasculitis

Aspirin:
Common (1% to 10%): Purpura
Frequency not reported: Erythema exsudativum multiforme

Dipyridamole:
Common (1% to 10%): Purpura[Ref]

Metabolic

Common (1% to 10%): Anorexia
Frequency not reported: Hyperglycemia, thirst
Postmarketing reports: Hyperkalemia, metabolic acidosis, hypokalemia, hypoglycemia, dehydration

Aspirin:
Common (1% to 10%): Anorexia
Frequency not reported: Hyperglycemia, thirst, dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

Dipyridamole:
Common (1% to 10%): Anorexia[Ref]

Psychiatric

Common (1% to 10%): Confusion
Frequency not reported: Agitation

Aspirin:
Common (1% to 10%): Confusion
Frequency not reported: Agitation

Dipyridamole:
Common (1% to 10%): Confusion[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Postmarketing reports: Rhabdomyolysis

Aspirin:
Common (1% to 10%): Back pain
Frequency not reported: Rhabdomyolysis

Dipyridamole:
Common (1% to 10%): Back pain[Ref]

Oncologic

Common (1% to 10%): Neoplasm not otherwise specified

Aspirin:
Common (1% to 10%): Neoplasm not otherwise specified

Dipyridamole:
Common (1% to 10%): Neoplasm not otherwise specified[Ref]

Hepatic

Frequency not reported: Cholelithiasis, jaundice, hepatic function abnormal
Postmarketing reports: Reye's syndrome, hepatitis, hepatic failure

Aspirin:
Frequency not reported: Hepatitis, Reye's syndrome[Ref]

Renal

Frequency not reported: Renal insufficiency, renal failure
Postmarketing reports: Interstitial nephritis, papillary necrosis

Aspirin:
Frequency not reported: Renal failure, interstitial nephritis, papillary necrosis[Ref]

Genitourinary

Frequency not reported: Uterine hemorrhage, hematuria
Postmarketing reports: Proteinuria

Aspirin:
Frequency not reported: Proteinuria[Ref]

Immunologic

Frequency not reported: Allergic reaction
Postmarketing reports: Hypersensitivity, acute anaphylaxis

Aspirin:
Frequency not reported: Anaphylactic reactions[Ref]

References

1. "Product Information. Aggrenox (aspirin-dipyridamole)" Boehringer-Ingelheim, Ridgefield, CT.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Aggrenox may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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