Medically reviewed by Drugs.com. Last updated on Jun 18, 2020.
(lif i TEG rast)
- Lifitegrast Sodium
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Xiidra: 5% (5 ea)
Solution, Ophthalmic [preservative free]:
Xiidra: 5% (5 ea)
Brand Names: U.S.
- Lymphocyte Function-Associated Antigen 1 (LFA-1) Antagonist
Lifitegrast binds to the integrin lymphocyte function-associated antigen-1 (LFA-1) and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1).
Use: Labeled Indications
Dry eye disease: Treatment of the signs and symptoms of dry eye disease (DED).
Hypersensitivity to lifitegrast or any component of the formulation.
Dry eye disease: Ophthalmic: Instill 1 drop into each eye every 12 hours.
Refer to adult dosing.
Dry eye disease (DED): Adolescents ≥17 years: Ophthalmic: Instill 1 drop into each eye every 12 hours.
For topical ophthalmic use only. Remove contact lenses prior to administration and wait 15 minutes before reinserting. Do not touch the eye or surrounding area or any surface with the dropper tip to avoid contamination; discard single use container and unused solution after administration.
Store at 20°C to 25°C (68°F to 77°F). Store single-use containers in the original foil pouch.
There are no known significant interactions.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Gastrointestinal: Dysgeusia (5% to 25%)
Local: Application site irritation (5% to 25%)
Ophthalmic: Decreased visual acuity (5% to 25%)
1% to 10%:
Central nervous system: Headache (1% to 5%)
Ophthalmic: Blurred vision (1% to 5%), conjunctival hyperemia (1% to 5%), eye discharge (1% to 5%), eye discomfort (1% to 5%), eye irritation (1% to 5%), eye pruritus (1% to 5%), increased lacrimation (1% to 5%)
Respiratory: Sinusitis (1% to 5%)
Postmarketing: Hypersensitivity reactions (allergic conjunctivitis, allergic dermatitis, anaphylaxis, angioedema, bronchospasm, dyspnea, pharyngeal edema, respiratory distress, swollen tongue, urticaria), skin rash, swelling of eye
• Contact lens wearers: Remove contact lens prior to administration and wait 15 minutes before reinserting.
Systemic exposure following ophthalmic administration is low. In general, if ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease potential exposure to the fetus (Samples 1988).
What is this drug used for?
• It is used to treat dry eyes.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
• Eye irritation
• Change in taste
• Blurred vision
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Frequently Asked Questions
- Can I use other eye drops with Xiidra?
- How long does it take for Xiidra to work?
- How much is Xiidra without insurance?
More about lifitegrast ophthalmic
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- En Español
- 196 Reviews
- Drug class: ophthalmic anti-inflammatory agents
Other brands: Xiidra