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Lifitegrast

Medically reviewed by Drugs.com. Last updated on Jun 18, 2020.

Pronunciation

(lif i TEG rast)

Index Terms

  • Lifitegrast Sodium

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Xiidra: 5% (5 ea)

Solution, Ophthalmic [preservative free]:

Xiidra: 5% (5 ea)

Brand Names: U.S.

  • Xiidra

Pharmacologic Category

  • Lymphocyte Function-Associated Antigen 1 (LFA-1) Antagonist

Pharmacology

Lifitegrast binds to the integrin lymphocyte function-associated antigen-1 (LFA-1) and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1).

Use: Labeled Indications

Dry eye disease: Treatment of the signs and symptoms of dry eye disease (DED).

Contraindications

Hypersensitivity to lifitegrast or any component of the formulation.

Dosing: Adult

Dry eye disease: Ophthalmic: Instill 1 drop into each eye every 12 hours.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Dry eye disease (DED): Adolescents ≥17 years: Ophthalmic: Instill 1 drop into each eye every 12 hours.

Administration

For topical ophthalmic use only. Remove contact lenses prior to administration and wait 15 minutes before reinserting. Do not touch the eye or surrounding area or any surface with the dropper tip to avoid contamination; discard single use container and unused solution after administration.

Storage

Store at 20°C to 25°C (68°F to 77°F). Store single-use containers in the original foil pouch.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

>10%:

Gastrointestinal: Dysgeusia (5% to 25%)

Local: Application site irritation (5% to 25%)

Ophthalmic: Decreased visual acuity (5% to 25%)

1% to 10%:

Central nervous system: Headache (1% to 5%)

Ophthalmic: Blurred vision (1% to 5%), conjunctival hyperemia (1% to 5%), eye discharge (1% to 5%), eye discomfort (1% to 5%), eye irritation (1% to 5%), eye pruritus (1% to 5%), increased lacrimation (1% to 5%)

Respiratory: Sinusitis (1% to 5%)

Postmarketing: Hypersensitivity reactions (allergic conjunctivitis, allergic dermatitis, anaphylaxis, angioedema, bronchospasm, dyspnea, pharyngeal edema, respiratory distress, swollen tongue, urticaria), skin rash, swelling of eye

Warnings/Precautions

Special Populations:

• Contact lens wearers: Remove contact lens prior to administration and wait 15 minutes before reinserting.

Pregnancy Considerations

Systemic exposure following ophthalmic administration is low. In general, if ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease potential exposure to the fetus (Samples 1988).

Patient Education

What is this drug used for?

• It is used to treat dry eyes.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Eye irritation

• Change in taste

• Blurred vision

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions