Ciprofloxacin and Hydrocortisone
Medically reviewed by Drugs.com. Last updated on Jun 26, 2019.
(sip roe FLOKS a sin & hye droe KOR ti sone)
- Ciprofloxacin Hydrochloride and Hydrocortisone
- Hydrocortisone and Ciprofloxacin
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cipro HC: Ciprofloxacin hydrochloride 0.2% and hydrocortisone 1% (10 mL) [contains benzyl alcohol]
Brand Names: U.S.
- Cipro HC
- Antibiotic, Otic
- Antibiotic/Corticosteroid, Otic
- Corticosteroid, Otic
Use: Labeled Indications
Acute otitis externa: Treatment of acute otitis externa due to susceptible isolates of Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa.
Hypersensitivity to hydrocortisone, ciprofloxacin, or any member of the quinolone class of antimicrobial agents; viral infections of the external canal, including varicella and herpes simplex infections; perforated tympanic membrane (known or suspected).
Acute otitis externa: Otic: Instill 3 drops into affected ear twice daily for 7 days.
Refer to adult dosing.
Otitis externa, acute: Children and Adolescents: Otic: Instill 3 drops into the affected ear(s) twice daily for 7 days
For otic use only. Not for oral, nasal, or ocular use. Prior to instillation, bottle should be warmed by holding in hands for 1 to 2 minutes; dizziness can occur if a cold suspension is instilled. Shake suspension well immediately before using. Patient should lie with affected ear upward and remain in this position for 30 to 60 seconds following instillation. Repeat, if necessary, for the opposite ear.
Store below 25°C (77°F); avoid freezing. Protect from light.
There are no known significant interactions.
See individual agents.
1% to 10%: Central nervous system: Headache (1%)
<1%, postmarketing, and/or case reports: Alopecia, cough, fungal dermatitis, hypersensitivity reaction, hypoesthesia, migraine, paresthesia, pruritus, skin rash, urticaria
Concerns related to adverse effects:
• Hypersensitivity: Severe and occasionally fatal hypersensitivity reactions, including anaphylaxis, have occurred with systemic fluoroquinolone therapy. Prompt discontinuation of drug should occur if skin rash or other symptoms of hypersensitivity arise.
• Infection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment. If superinfection occurs, discontinue use and institute appropriate therapy.
• Tendon inflammation/rupture: There have been reports of tendon inflammation and/or rupture with systemic fluoroquinolones. Exposure following otic administration is substantially lower than with systemic therapy. Discontinue at first sign of tendon inflammation or pain.
Dosage form specific issues:
• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.
• Appropriate use: For otic use only; not intended for injection or ophthalmic use.
Animal reproduction studies have not been conducted with this combination.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Have patient report immediately to prescriber severe ear irritation (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about ciprofloxacin / hydrocortisone otic
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug class: otic steroids with anti-infectives
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Other brands: Cipro HC