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Repatha SureClick

Generic name: evolocumabE-voe-LOK-ue-mab ]
Brand names: Repatha Prefilled Syringe, Repatha Pushtronex, Repatha SureClick, Repatha Autoinjector
Drug class: PCSK9 inhibitors

Medically reviewed by on Aug 21, 2023. Written by Cerner Multum.

What is Repatha SureClick?

Repatha SureClick works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood.

Repatha SureClick is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries.

Repatha SureClick is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis).

Repatha SureClick may also be used for purposes not listed in this medication guide.

Repatha SureClick side effects

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat.

Repatha SureClick may cause serious side effects. Call your doctor at once if you have:

Common side effects of Repatha SureClick may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Repatha SureClick if you are allergic to it.

Tell your doctor if you have ever had:

  • liver or kidney disease; or

  • a latex allergy.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of evolocumab on the baby.

It may not be safe to breast-feed while using Repatha SureClick. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Repatha SureClick is not approved for use by anyone younger than 13 years old. For certain conditions, this medicine should not be given to a child of any age.

How is Repatha SureClick given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Repatha SureClick is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Repatha SureClick is available in a prefilled syringe, a SureClick prefilled autoinjector, or a Pushtronex on-body infusor with prefilled cartridge. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you have questions, or call the manufacturer at 1-844-737-2842.

The Pushtronex on-body infusor is a special device placed on the skin that delivers your Repatha SureClick dose slowly. You will need to wear the device for about 9 minutes to get the full dose. While wearing the on-body infusor, you may perform moderate activities such as walking, bending, or reaching.

Your care provider will show you the best places on your body to inject Repatha SureClick or place the on-body infusor. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

Each single-use prefilled syringe, cartridge, or injection device is for one use only. Throw away after one use, even if there is still some medicine left inside. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Store Repatha SureClick in the refrigerator in its original carton and protect from light and heat. Do not freeze. Throw away any this medicine that has been frozen.

Take the medicine out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Do not heat a syringe or injection device.

You may also store Repatha SureClick in the original carton at cool room temperature, away from light and heat. Use the medicine within 30 days if it is kept at room temperature.

Handle this medicine carefully. Dropping an injection device can cause it to break. Do not use an injection device that has been dropped onto a hard surface, even if you cannot see a break in it. Call your pharmacist for new medicine.

Do not shake this medicine. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

You should not stop using Repatha SureClick without your doctor's advice, or your LDL cholesterol levels may increase.

Repatha SureClick is only part of a complete treatment program that also includes diet, statin medication, and regular blood testing. Follow your doctor's instructions very closely.

What happens if I miss a dose?

Use the missed dose within 7 days after that injection was due, but skip the missed dose if you are more than 7 days late. After a missed dose, go back to your original schedule and use the medicine again when your next scheduled dose is due.

Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Repatha SureClick?

Do not inject Repatha SureClick into skin that is bruised, sore, scarred, or hardened.

What other drugs will affect Repatha SureClick?

Other drugs may affect Repatha SureClick, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

A serious danger of taking Repatha (evolocumab) includes a possibly life-threatening allergic reaction. Also tell your doctor if you are allergic to rubber or latex. Other side effects, which could be serious in some people, include high blood sugar levels (diabetes), respiratory tract infections, urinary tract infections (UTI), high blood pressure, and influenza (flu). Continue reading

The PCSK9 inhibitors are used for the treatment of high-risk patients with elevated cholesterol, especially when statins aren't adequate. They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood. Continue reading

You can inject Repatha at any time of the day, but usually people prefer injecting Repatha during daylight hours because it takes 30 to 45 minutes for it to warm up to room temperature, and you need to be able to easily see what you are doing while you are injecting it. Continue reading

Repatha can be left unrefrigerated for up to 30 days at room temperature between 68°F to 77°F (20°C to 25°C) as long as it is kept in its original box and is not kept somewhere that gets hotter than 77°F (25°C), for example, a car glove box. This makes it easier to take your medicine with you when you’re on the go. Do not put Repatha back in the refrigerator once you have taken it out. Continue reading

Repatha can cause high blood pressure (hypertension) as a side effect. Continue reading

Instructions on how to inject Repatha using Repatha prefilled syringe, Repatha SureClik Autoinjector, and the Pushtronex system (Repatha on-body infusor) for Repatha. Continue reading

The cost for Repatha (evolocumab) subcutaneous solution (140 mg/mL) is about $258.00 for one of the 140 mg single-use prefilled autoinjectors or a prefilled syringe. The 2-pack carton costs roughly $507. Continue reading

Repatha (evolocumab) is a monoclonal antibody that inhibits PCSK9 (proprotein convertase subtilisin kexin type 9). PCSK9 is a protein found in the liver that plays a key role in plasma cholesterol metabolism.

Once administered it binds to PCSK9 and prevents the circulating PCSK9 from binding to LDL receptors. This increases the amount of LDL receptors available to clear the ‘bad’ LDL cholesterol from the blood.

Continue reading

The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, number of treatment indications, dosage forms available and number of strengths available in syringe and pens forms. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.