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Morphine (injection)

Generic Name: morphine (injection) (MOR feen)
Brand Name: Duramorph PF, Infumorph, Mitigo
Dosage Forms: injectable solution (0.5 mg/mL preservative-free; 1 mg/mL; 1 mg/mL preservative-free; 1 mg/mL-NaCl 0.9% preservative-free; 10 mg/mL preservative-free; 2 mg/mL preservative-free; 25 mg/mL preservative-free; 4 mg/mL preservative-free; 5 mg/mL preservative-free; 50 mg/mL; 8 mg/mL; 8 mg/mL preservative-free); intravenous solution (0.5 mg/mL-NaCl 0.9%; 0.5 mg/mL-NaCl 0.9% preservative-free; 1 mg/mL preservative-free; 1 mg/mL-D5%; 1 mg/mL-NaCl 0.9%; 1 mg/mL-NaCl 0.9% preservative-free; 10 mg/mL preservative-free; 2 mg/mL preservative-free; 2 mg/mL-D5%; 2 mg/mL-NaCl 0.9%; 25 mg/mL preservative-free; 4 mg/mL preservative-free; 4 mg/mL-NaCl 0.9% preservative-free; 5 mg/mL preservative-free; 5 mg/mL-NaCl 0.9%; 8 mg/mL preservative-free)

Medically reviewed by Drugs.com on Nov 22, 2019. Written by Cerner Multum.

What is morphine?

Morphine is an opioid medication used to treat severe chronic pain.

Morphine may also be used for purposes not listed in this medication guide.

Warnings

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Using opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not use morphine if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have:

  • severe asthma or breathing problems; or

  • a blockage in your stomach or intestines.

Do not use morphine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

It may not be safe to breastfeed while using morphine. This medicine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby. Ask your doctor about any risk.

Morphine injection is not approved for use by anyone younger than 18 years old.

How is morphine injection given?

Follow the directions on your prescription label and read all medication guides. Never use morphine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.

Morphine is injected into a muscle, or given as an infusion into a vein. Morphine injection is sometimes given with an infusion pump that controls your dosing.

Morphine is sometimes injected into the space around the spinal cord, or directly into the fluid around the brain and spinal cord. A healthcare provider will give this type of injection in a hospital.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat. Keep the auto-injector in its original container until you are ready to use it.

Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Because you will receive morphine in a hospital or with a controlled infusion pump, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A morphine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, very slow breathing, or coma.

What should I avoid while using morphine?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how morphine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Morphine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • slow heart rate, sighing, shallow breathing, breathing that stops during sleep;

  • extreme drowsiness, feeling like you might pass out;

  • flushing (sudden warmth, redness, or tingly feeling);

  • a seizure; or

  • low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

  • breathing problems;

  • drowsiness, dizziness;

  • constipation, nausea, vomiting;

  • sweating; or

  • numbness, tingling, or cold feeling in your hands and feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect morphine?

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may affect morphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.