Generic Name: morphine (injection) (MOR feen)
Brand Name: Duramorph PF, Infumorph, Mitigo
What is Mitigo?
Mitigo is an opioid medicine used to treat severe chronic pain.
Mitigo may also be used for purposes not listed in this medication guide.
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Using opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Before taking this medicine
You should not use Mitigo if you have ever had an allergic reaction to Mitigo or other opioid medicines, or if you have:
severe asthma or breathing problems;
Tell your doctor if you have ever had:
breathing problems, sleep apnea (breathing that stops during sleep);
a drug or alcohol addiction, or mental illness;
liver or kidney disease; or
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.
Mitigo is not approved for use by anyone younger than 18 years old.
How is Mitigo given?
Follow the directions on your prescription label and read all medication guides. Never use Mitigo in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Mitigo is injected into a muscle, or given as an infusion into a vein. This medicine injection is sometimes given with an infusion pump that controls your dosing.
Mitigo is sometimes injected into the space around the spinal cord, or directly into the fluid around the brain and spinal cord. A healthcare provider will give this type of injection in a hospital.
Do not stop using Mitigo suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat. Keep the auto-injector in its original container until you are ready to use it.
Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
What happens if I miss a dose?
Because you will receive Mitigo in a hospital or with a controlled infusion pump, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.
Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.
Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.
What should I avoid while using Mitigo?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how Mitigo will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Mitigo side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
slow heart rate, sighing, shallow breathing, breathing that stops;
extreme drowsiness, feeling like you might pass out;
flushing (sudden warmth, redness, or tingly feeling);
low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
constipation, nausea, vomiting;
numbness, tingling, or cold feeling in your hands and feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Mitigo?
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
other opioids--opioid pain medicine or prescription cough medicine;
drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, tranquilizer, antidepressant, or antipsychotic medicine; or
More about Mitigo (morphine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: narcotic analgesics
- Latest FDA Alerts (10)
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2021 Cerner Multum, Inc. Version: 2.01.