Generic Name: hydrochlorothiazide (HYE dro KLOR o THY a zide)
Brand Name: Microzide
What is Microzide (hydrochlorothiazide)?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Hydrochlorothiazide is used to treat high blood pressure (hypertension).
Hydrochlorothiazide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Microzide (hydrochlorothiazide)?
You should not use this medicine if you are unable to urinate.
What should I discuss with my healthcare provider before taking Microzide (hydrochlorothiazide)?
You should not use hydrochlorothiazide if you are allergic to it, or if you are unable to urinate.
To make sure hydrochlorothiazide is safe for you, tell your doctor if you have:
low levels of potassium or sodium in your blood;
high levels of calcium in your blood;
a parathyroid gland disorder;
an allergy to sulfa drugs or penicillin.
Hydrochlorothiazide is not expected to be harmful to an unborn baby. However, if you take this medicine during pregnancy, your newborn baby may develop jaundice or other problems. Tell your doctor if you are pregnant or plan to become pregnant while taking hydrochlorothiazide.
Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Hydrochlorothiazide is not approved for use by anyone younger than 18 years old.
How should I take Microzide (hydrochlorothiazide)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Hydrochlorothiazide is usually taken once per day. Follow your doctor's dosing instructions very carefully.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance.
While using hydrochlorothiazide, you may need frequent medical tests and blood pressure be checks. Your blood and urine may both be tested if you have been vomiting or are dehydrated.
If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide. You may need to stop using the medicine for a short time.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture, heat, and freezing. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include nausea, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness.
What should I avoid while taking Microzide (hydrochlorothiazide)?
Drinking alcohol with this medicine can cause side effects.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Microzide (hydrochlorothiazide) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
eye pain, vision problems;
jaundice (yellowing of the skin or eyes);
pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);
shortness of breath, wheezing, cough with foamy mucus, chest pain;
signs of electrolyte imbalance--dry mouth, thirst, drowsiness, lack of energy, restlessness, muscle pain or weakness, fast heart rate, nausea and vomiting, little or no urine; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
nausea, vomiting, loss of appetite;
muscle spasm; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Microzide (hydrochlorothiazide)?
Taking this medicine with other drugs that make you light-headed can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
insulin or oral diabetes medicine;
other blood pressure medications;
steroid medicine; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with hydrochlorothiazide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Microzide (hydrochlorothiazide)
- Other brands: Aquazide H
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about hydrochlorothiazide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 12.01.
Last reviewed: August 09, 2016
Date modified: January 10, 2017