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Hyoscyamine, methenamine, methylene blue, and sodium biphosphate

Generic Name: hyoscyamine, methenamine, methylene blue, and sodium biphosphate (HYE oh SYE a meen, meth EN a meen, METH il een BLUE, SOE dee um bye FOS fate)
Brand Name: Urogesic-Blue, UTA, Uro-BLUE, Urolet MB, Indiomin MB

Medically reviewed on February 1, 2018

What is hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder.

Sodium biphosphate is a form of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate is a combination medicine used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. hyoscyamine, methenamine, methylene blue, and sodium biphosphate is also used to prevent bladder discomfort during a medical procedure.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate may also be used for purposes not listed in this medication guide.

Important Information

If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and sodium biphosphate.

Before taking this medicine

You should not use this medicine if you are allergic to hyoscyamine, methenamine, methylene blue, or sodium biphosphate.

To make sure this medicine is safe for you, tell your doctor if you have:

It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

This medicine should not be given to a child younger than 7 years old.

How should I take hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break an enteric coated pill. Swallow it whole. The pill has a special coating to protect your stomach. Breaking the pill will damage this coating.

Drink plenty of liquids while you are taking this medication.

If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and sodium biphosphate.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, and sodium biphosphate. Antacids or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, and sodium biphosphate.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate side effects

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using hyoscyamine, methenamine, methylene blue, and sodium biphosphate and call your doctor at once if you have:

Older adults may be more likely to have side effects from this medication.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate dosing information

Usual Adult Dose for Urinary Tract Infection:

Hyoscyamine/methenamine/m-blue/sodium biphosphate 0.12 mg-81.6 mg-10.8 mg-40.8 mg oral tablet:
1 tablet orally four times daily.

What other drugs will affect hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Many drugs can interact with this medicine. Not all possible interactions are listed here. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all your medications and any you start or stop using, especially:

This list is not complete and many other drugs can interact with hyoscyamine, methenamine, methylene blue, and sodium biphosphate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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