Skip to main content

Hydromorphone (injection)

Generic name: hydromorphone (injection) (hy dro MOR fone)
Brand name: Dilaudid
Dosage forms: injectable solution (0.2 mg/mL; 0.5 mg/0.5 mL; 0.5 mg/mL-NaCl 0.9%; 1 mg/mL; 1 mg/mL-NaCl 0.9%; 10 mg-0.9%/50 mL; 10 mg/mL; 2 mg/10 mL-NaCl 0.9%; 2 mg/mL; 4 mg/mL; 4 mg/mL-NaCl 0.9%; 6 mg/30 mL-NaCl 0.9%); intravenous solution (0.04 mg/mL-NaCl 0.9%; 0.1 mg/mL-NaCl 0.9%; 0.2 mg/mL-NaCl 0.9%; 0.4 mg/mL-NaCl 0.9%; 0.5 mg/5 mL-D5%; 0.5 mg/mL-NaCl 0.9%; 0.6 mg/0.6 mL-NaCl 0.9%; 1 mg/mL-NaCl 0.9%; 10 mg-0.9%/50 mL; 100 mg/50 mL-D5%; 2 mg/mL-NaCl 0.9%; 25 mg-0.9%/50 mL; 3 mg/30 mL-D5%)
Drug class: Narcotic analgesics

Medically reviewed by Drugs.com on Jun 15, 2021. Written by Cerner Multum.

What is hydromorphone injection?

Hydromorphone injection is an opioid medicine used to treat moderate to severe pain.

Hydromorphone injection may also be used for purposes not listed in this medication guide.

Warnings

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it.

Using opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not use hydromorphone if you have ever had an allergic reaction to a narcotic medicine, or if you have:

Do not use hydromorphone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

If you use opioid medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

How is hydromorphone injection given?

Hydromorphone is injected into a muscle, under the skin, or into a vein.

Hydromorphone is usually given by injection only if you are unable to take medicine by mouth.

Never share opioid medicine with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away hydromorphone is against the law.

You may have withdrawal symptoms if you stop using hydromorphone suddenly. Ask your doctor before stopping the medicine.

Free Drugs.com Discount Card

  • Save up to 80% on your prescriptions.
  • Accepted at over 65,000 pharmacies.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or person using opioid medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving hydromorphone injection?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how hydromorphone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Hydromorphone injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing, breathing that stops during sleep;

  • severe drowsiness;

  • a light-headed feeling, like you might pass out; or

  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects may include:

  • constipation, nausea, vomiting;

  • dizziness, drowsiness;

  • flushing (warmth, redness, or tingly feeling);

  • sweating, itching;

  • dry mouth; or

  • mood changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydromorphone injection?

Many other drugs can be dangerous when used with opioid medicine. Tell your doctor if you also use:

This list is not complete. Many drugs may affect hydromorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.