What is sodium hyaluronate?
Sodium hyaluronate is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.
Sodium hyaluronate is usually given when other arthritis medications have not been effective.
Sodium hyaluronate may also be used for purposes not listed in this medication guide.
You should not receive a Gel-One if you have an infection in your knee or in the skin around your knee.
Before taking this medicine
You should not receive sodium hyaluronate if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.
To make sure sodium hyaluronate is safe for you, tell your doctor if you have ever had:
blood clots or circulation problems in your legs; or
an allergy to birds, feathers, or egg products.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether sodium hyaluronate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How is sodium hyaluronate given?
Sodium hyaluronate is injected directly into your knee joint. A healthcare provider will give you this injection.
Sodium hyaluronate is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.
To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Gel-One.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving sodium hyaluronate?
For at least 48 hours after your injection, avoid jogging, strenuous activity, or high-impact sports such as soccer or tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time. Ask your doctor how long to wait before you resume these activities.
Sodium hyaluronate side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe pain or swelling around the knee after the injection.
Common side effects may include:
warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
nausea, stomach pain;
numbness or tingly feeling;
runny or stuffy nose, sneezing, sore throat.
tired feeling; or
itching or skin irritation around the knee.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect sodium hyaluronate?
Other drugs may interact with sodium hyaluronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about sodium hyaluronate
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- 191 Reviews – Add your own review/rating
- Drug class: viscosupplementation agents
- Sodium hyaluronate injection
- Hyaluronate and Derivatives Injection (Knee)
- Hyaluronate sodium Injection (Advanced Reading)
Related treatment guides
Where can I get more information?
- Your doctor can provide more information about sodium hyaluronate.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01.
Date modified: February 01, 2018
Last reviewed: October 02, 2017