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Generic Name: estramustine (ES tra MUS teen)
Brand Name: Emcyt

Medically reviewed by on Sep 19, 2019 – Written by Cerner Multum

What is Emcyt?

Emcyt is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Emcyt is used to treat metastatic or progressive prostate cancer.

Emcyt may also be used for purposes not listed in this medication guide.

Important Information

You should not use Emcyt if you have a blood clot, swelling of a vein caused by a blood clot, or if you have ever had an allergic reaction to estradiol or nitrogen mustard.

Before taking this medicine

You should not use Emcyt if you are allergic to it, or if you have:

  • a blood clot;

  • swelling of a vein caused by a blood clot; or

  • if you have ever had an allergic reaction to estradiol or nitrogen mustard.

To make sure Emcyt is safe for you, tell your doctor if you have:

If a man fathers a baby while using Emcyt, the baby may have birth defects. Use condoms to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking this medicine.

How should I take Emcyt?

Follow all directions on your prescription label. Do not take Emcyt in larger or smaller amounts or for longer than recommended.

Take Emcyt on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take this medicine with water, not with milk or other dairy products.

It may take up to 90 days before you receive the full benefit of taking Emcyt. Your doctor will determine how long to treat you with this medicine.

While using Emcyt, you may need frequent blood tests. Your blood pressure will also need to be checked often.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Emcyt.

Store in the refrigerator, do not freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Emcyt?

Do not take this medication with milk, milk products, calcium supplements, or calcium-rich foods such as ice cream, yogurt, broccoli, and others.

Avoid using antacids or vitamin/mineral supplements that contain calcium. Calcium can make it harder for your body to absorb Emcyt.

Emcyt can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Emcyt side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Emcyt and call your doctor at once if you have:

  • heart problems--shortness of breath (even with mild exertion), swelling, rapid weight gain, chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs; or

  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Emcyt?

Other drugs may interact with estramustine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.