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Difluprednate ophthalmic

Generic Name: difluprednate ophthalmic (DYE floo PRED nate off THAL mik)
Brand Name: Durezol

Medically reviewed by Drugs.com on Nov 14, 2018 – Written by Cerner Multum

What is difluprednate ophthalmic?

Difluprednate ophthalmic (for the eyes) is a steroid medicine that is used to treat eye pain and inflammation caused by surgery.

Difluprednate ophthalmic is also used to treat anterior uveitis, inflammation that affects the front part of the eye.

Difluprednate ophthalmic may also be used for purposes not listed in this medication guide.

Important Information

You should not use difluprednate ophthalmic if you have any type of bacterial, fungal, or viral infection of the eye (including herpes).

Before taking this medicine

You should not use difluprednate if you are allergic to it, or if you have any type of bacterial, fungal, or viral infection of the eye (including herpes).

Tell your doctor if you have ever had:

It is not known whether difluprednate ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I use difluprednate ophthalmic?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor may prescribe 2 separate bottles of difluprednate ophthalmic, one to use in each eye. This is to keep from passing infection from one eye to the other. Be sure to mark each bottle for the right or left eye, and use the eye drops from that bottle only in that eye.

Wash your hands before using the eye drops.

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your eyes for 1 or 2 minutes.

Use only the number of drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use while wearing soft contact lenses. Use the medicine at least 10 minutes before inserting your contact lenses.

Call your doctor if your symptoms do not improve after 2 days of treatment.

If you use this medicine for longer than 10 days, you may need frequent vision tests to check the pressure inside your eyes.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

You should not stop using this medicine suddenly. Follow your doctor's instructions about tapering your dose.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using difluprednate ophthalmic?

difluprednate ophthalmic may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Do not share this medicine with another person, even if they have the same symptoms you have.

Difluprednate ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pain behind your eyes, sudden vision changes;

  • slow healing after your eye surgery;

  • eye pain, tunnel vision, or seeing halos around lights; or

  • signs of new eye infection, such as swelling, draining, or crusting of your eyes.

Common side effects may include:

  • eye itching or irritation;

  • blurred vision;

  • watery eyes;

  • headache;

  • feeling like something is in your eye; or

  • your eyes may be more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Difluprednate ophthalmic dosing information

Usual Adult Dose for Postoperative Ocular Inflammation:

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times per day for a week and then a taper based on the response

Use: Treatment of inflammation and pain associated with ocular surgery

Usual Adult Dose for Uveitis:

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day for 14 days followed by tapering as clinically indicated

Use: Treatment of endogenous anterior uveitis

Usual Pediatric Dose for Postoperative Ocular Inflammation:

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times per day for a week and then a taper based on the response

Use: Treatment of inflammation and pain associated with ocular surgery

Usual Pediatric Dose for Uveitis:

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day for 14 days followed by tapering as clinically indicated

Use: Treatment of endogenous anterior uveitis

What other drugs will affect difluprednate ophthalmic?

Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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