Difluprednate Ophthalmic Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 17, 2025.
Applies to difluprednate ophthalmic: ophthalmic emulsion.
Precautions
Your eye doctor will want to examine your eye(s) at regular visits to make sure the medicine is working properly and is not causing unwanted effects.
Difluprednate eye drops are not for long-term use. Steroid eye drops may cause glaucoma (increased pressure inside the eye) or posterior subcapsular cataracts (a rare type of cataract) if used too long Slow or delayed healing may also occur while you are using this medicine after cataract surgery. You will need to have regular eye exams with your doctor to check for these problems.
If you hurt your eye or develop an eye infection, talk with your doctor right away. You may need to change your medicine or stop using it.
If your symptoms do not improve or if your condition becomes worse, check with your doctor.
Serious side effects
Along with its needed effects, difluprednate ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking difluprednate ophthalmic:
More common side effects
- blurred vision
- change in color vision
- decreased vision or other changes in vision
- difficulty seeing at night
- eye discomfort
- eye pain
- eye redness
- increase in blood flow to the whites of the eyes
- increased sensitivity of the eyes to sunlight
- painful irritation of the front clear part of the eye
- sensitivity of the eyes to light
- swelling or redness of the eye and lining of the eyelid
Less common side effects
- eyelid irritation and crusting
- tearing
- throbbing eye pain
- watering of the eyes
Other side effects
Some side effects of difluprednate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- dry eyes
Rare side effects
- burning, itching, or soreness of the eye
- feeling of having something in the eye
See also:
Humira
Humira is a tumor necrosis factor blocker used to treat many inflammatory conditions in adults ...
Imuran
Imuran is used for atopic dermatitis, autoimmune hepatitis, chronic active hepatitis, chronic ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
TobraDex
Tobradex (tobramycin, dexamethasone) is used to treat bacterial infections of the eyes. Includes ...
Maxitrol
Maxitrol is used for blepharitis, conjunctivitis, bacterial, keratitis, keratoconjunctivitis, uveitis
Cortisone
Cortisone is used for adrenal insufficiency, ankylosing spondylitis, berylliosis, bursitis ...
Atropine ophthalmic
Atropine ophthalmic is used for pupillary dilation, refraction, assessment, uveitis
Adalimumab
Adalimumab is used to treat plaque psoriasis, Crohn's disease, ulcerative colitis, rheumatoid ...
Azathioprine
Azathioprine is used for atopic dermatitis, autoimmune hepatitis, behcet's disease, bullous ...
Triamcinolone ophthalmic
Triamcinolone ophthalmic is used for macular edema, temporal arteritis, uveitis, vitrectomy
For healthcare professionals
Applies to difluprednate ophthalmic: ophthalmic emulsion.
General adverse events
The most commonly reported side effects were elevated intraocular pressure, visual acuity and field defects, and posterior subcapsular cataract formation.[Ref]
Ocular
- Common (1% to 10%): Corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, blepharitis, reduced visual acuity, punctate keratitis, eye inflammation, iritis, blurred vision, eye irritation
- Uncommon (0.1% to 1%): Corneal pigmentation and striae, episcleritis, eye pruritus, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, sclera hyperemia, uveitis, increased intraocular pressure, iritis, limbal and conjunctival hyperemia, dry eye, iridocyclitis[Ref]
Local
- Uncommon (0.1% to 1%): Application site discomfort or irritation[Ref]
Nervous system
References
1. (2008) "Product Information. Durezol (difluprednate ophthalmic)." Sirion Therapeutics
More about difluprednate ophthalmic
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (24)
- Dosage information
- During pregnancy
- Drug class: ophthalmic steroids
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Difluprednate ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.