Difluprednate Ophthalmic Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 17, 2025.

Applies to difluprednate ophthalmic: ophthalmic emulsion.

Precautions

Your eye doctor will want to examine your eye(s) at regular visits to make sure the medicine is working properly and is not causing unwanted effects.

Difluprednate eye drops are not for long-term use. Steroid eye drops may cause glaucoma (increased pressure inside the eye) or posterior subcapsular cataracts (a rare type of cataract) if used too long Slow or delayed healing may also occur while you are using this medicine after cataract surgery. You will need to have regular eye exams with your doctor to check for these problems.

If you hurt your eye or develop an eye infection, talk with your doctor right away. You may need to change your medicine or stop using it.

If your symptoms do not improve or if your condition becomes worse, check with your doctor.

Serious side effects

Along with its needed effects, difluprednate ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking difluprednate ophthalmic:

Other side effects

Some side effects of difluprednate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to difluprednate ophthalmic: ophthalmic emulsion.

General adverse events

The most commonly reported side effects were elevated intraocular pressure, visual acuity and field defects, and posterior subcapsular cataract formation.^[Ref]

Ocular

• Common (1% to 10%): Corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, blepharitis, reduced visual acuity, punctate keratitis, eye inflammation, iritis, blurred vision, eye irritation
• Uncommon (0.1% to 1%): Corneal pigmentation and striae, episcleritis, eye pruritus, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, sclera hyperemia, uveitis, increased intraocular pressure, iritis, limbal and conjunctival hyperemia, dry eye, iridocyclitis^[Ref]

Local

• Uncommon (0.1% to 1%): Application site discomfort or irritation^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

Further information

Difluprednate ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer