Depo-Provera Contraceptive (injection)
What is medroxyprogesterone?
Medroxyprogesterone is a form of progesterone, a female hormone that prevents ovulation (the release of an egg from an ovary). This medicine also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.
Medroxyprogesterone is also used to ease pain and other symptoms in women with metastatic uterine or kidney cancer. This medicine is not a cure for these conditions.
Medroxyprogesterone may also be used for purposes not listed in this medication guide.
Medroxyprogesterone can cause birth defects. Do not use if this medicine if you are pregnant. Tell your doctor right away if you become pregnant during or soon after treatment with medroxyprogesterone.
You should not use this medicine for longer than 2 years. Medroxyprogesterone can decrease the calcium stored in your bones, which may cause bone loss (osteoporosis).
Before taking this medicine
Medroxyprogesterone can cause birth defects. Do not use if this medicine if you are pregnant. You may need to have a negative pregnancy test before you start this medicine. Tell your doctor right away if you become pregnant, or if you plan to become pregnant soon after you stop using medroxyprogesterone.
You should not use medroxyprogesterone if you are allergic to it, or if you have:
unusual vaginal bleeding;
a history of breast cancer; or
a history of heart attack, stroke, or blood clot.
You should not use this medicine for longer than 2 years. Medroxyprogesterone can decrease the calcium stored in your bones, which may cause bone loss (osteoporosis) when used over long periods of time. Bone loss may not be reversible. Ask your doctor about your specific risk.
To make sure medroxyprogesterone is safe for you, tell your doctor if you have:
breast nodules, or a family history of breast cancer;
a personal or family history of diabetes;
low bone mineral density, or a family history of osteoporosis;
depression, or an eating disorder;
light, heavy, or irregular menstrual periods;
a adrenal gland disorder;
if you have ever had a breast lump, an abnormal mammogram, or bleeding from your nipples; or
if you drink large amounts of alcohol or if you smoke.
If you are breast-feeding a baby, wait until your baby is at least 6 weeks old before using this medicine.
How should I use medroxyprogesterone?
Medroxyprogesterone is injected into a muscle or under the skin. Medroxyprogesterone may be given once per week or once every 3 months, depending on why you are using the medicine. Follow your doctor's instructions.
When used for birth control, medroxyprogesterone is given by a healthcare provider. For other conditions, you may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
You may have breakthrough bleeding while using medroxyprogesterone. Tell your doctor if this bleeding continues or is very heavy.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.
Your doctor will need to see you on a regular basis while you are using medroxyprogesterone. If you use this medicine long-term, your bone density may need to be checked during treatment.
Store at room temperature away from moisture and heat.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of this medicine.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using medroxyprogesterone?
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Medroxyprogesterone side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
menstrual periods that are heavier or longer than normal;
severe pain in your lower stomach;
swelling in your face, or your hands, ankles, and feet;
pain, bleeding, oozing (pus), or skin changes where the injection was given;
symptoms of depression (sleep problems, weakness, mood changes);
signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.
Common side effects may include:
changes in your menstrual periods;
swelling, weight gain (especially in your face);
mild stomach pain; or
feeling weak, tired, or nervous.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect medroxyprogesterone?
Tell your doctor about all your current medicines and any you start or stop using, especially:
an antibiotic or antifungal medicine;
HIV or AIDS medicine;
seizure medicine; or
sleep medicine (to treat insomnia).
This list is not complete. Other drugs may interact with medroxyprogesterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Depo-Provera Contraceptive (medroxyprogesterone)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 10 Reviews – Add your own review/rating
- Drug class: contraceptives
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about medroxyprogesterone.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01.
Date modified: March 06, 2018
Last reviewed: April 13, 2017