Generic Name: bupropion (byoo PRO pee on)
Brand Name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Wellbutrin, Budeprion SR, Budeprion XL
What is bupropion?
Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.
Bupropion may also be used for purposes not listed in this medication guide.
What is the most important information I should know about bupropion?
You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.
Do not use bupropion within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
What should I discuss with my healthcare provider before taking bupropion?
You should not take bupropion if you are allergic to it, or if you have:
a seizure disorder;
an eating disorder such as anorexia or bulimia; or
if you have suddenly stopped using alcohol, seizure medication, or a sedative such as Xanax, Valium, Fiorinal, Klonopin, and others).
Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Do not take bupropion to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking.
Bupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.
To make sure bupropion is safe for you, tell your doctor if you have:
a history of head injury, seizures, or brain or spinal cord tumor;
heart disease, high blood pressure, history of heart attack;
kidney or liver disease (especially cirrhosis);
bipolar disorder or other mental illness; or
if you drink alcohol.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Bupropion is not approved for use by anyone younger than 18 years old.
How should I take bupropion?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure.
You may take bupropion with or without food.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
You should not change your dose or stop using bupropion suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using bupropion.
If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 weeks.
Your doctor may prescribe nicotine patches or gum to help you stop smoking. Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.
Smoking cessation may also cause new or worsening mental health problems, such as depression.
Bupropion can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.
What should I avoid while taking bupropion?
Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in a regular drinker who suddenly stops drinking at the start of treatment with bupropion.
Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Bupropion side effects
Get emergency medical help if you have signs of an allergic reaction: hives, rash or itching; fever, swollen glands, joint pain, general ill feeling; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
a seizure (convulsions);
unusual changes in mood or behavior;
a manic episode--racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
fast heartbeats; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
dry mouth, stuffy nose;
sleep problems (insomnia);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Bupropion dosing information
Usual Adult Dose for Depression:
-Initial dose: 100 mg orally twice a day, increase if necessary after 3 days to 100 mg orally three times a day.
-Maintenance dose: 100 mg orally three times a day
-Maximum dose: 450 mg/day in up to 4 divided doses; single doses should not exceed 150 mg
-Initial dose: 150 mg orally once a day in the morning, increase if necessary after 3 days to 150 mg orally twice a day.
-Maintenance dose: 150 mg orally twice a day
-Maximum dose: 400 mg/day; maximum single dose should not exceed 200 mg
-Initial dose: 150 mg orally once a day in the morning, increase if necessary after 4 days to 300 mg orally once a day.
-Maintenance dose: 300 mg orally once a day
-Maximum dose: 450 mg/day
-Initial dose: 174 mg orally once a day in the morning, increase if necessary after 4 days to 348 mg orally once a day.
-Maintenance dose: 348 mg orally once a day
-Doses of immediate-release oral tablets should be given at least 6 hours apart.
-Doses of sustained-release oral tablets should be given at least 8 hours apart.
-Doses of extended-release oral tablets should be given at least 24 hours apart.
-Dose increases of the immediate-release tablet should not exceed 100 mg per day in a 3-day period.
-So as not to exceed the maximum single dose of 150 mg for immediate-release tablets, a dose of 100 mg orally four times a day (using the 100 mg tablet) may be administered.
-Patients who are taking 300 mg/day for at least 2 weeks (OR are currently taking 450 mg/day) of any formulation may be switched to the extended-release 450 mg dose.
-Bupropion hydrobromide 174 mg oral tablet is equivalent to bupropion hydrochloride 150 mg.
-Patients should be periodically reviewed to determine the need for maintenance treatment and the appropriate dose for such treatment.
Use: Treatment of major depressive disorder
Usual Adult Dose for Seasonal Affective Disorder:
-Initial dose: 150 mg orally once a day in the morning, increased if necessary after 7 days to 300 mg orally once a day
-Maintenance dose: 150 to 300 mg orally once a day
-Maximum dose: 300 mg/day
-Initial dose: 174 mg orally once a day, increased if necessary after 7 days to 348 mg orally once a day
-Maintenance dose: 348 mg orally once a day
-Maximum dose: 348 mg/day
-Treatment should be initiated in the autumn prior to the onset of depressive symptoms, continued through the winter season, and discontinued in early spring.
-If bupropion hydrochloride 300 mg orally per day is not tolerated, it should be reduced to 150 mg once a day before discontinuing treatment.
-Patients taking bupropion hydrochloride 300 mg orally per day during the autumn-winter season should have their dose tapered to 150 mg once a day for 2 weeks prior to discontinuation.
-When discontinuing bupropion hydrobromide in patients treated with 348 mg orally once a day, the dose should be reduced to 174 mg once a day prior to discontinuation.
-The timing of initiation and treatment duration for seasonal affective disorder should be individualized according to the patient's historical pattern of seasonal major depressive episodes.
Use: Prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD)
Usual Adult Dose for Smoking Cessation:
-Initial dose: 150 mg orally once a day for 3 days, increased to 150 mg orally twice a day
-Maintenance dose: 150 mg orally twice a day
-Maximum dose: 300 mg/day; maximum single dose should not exceed 150 mg
-Duration of therapy: 7 to 12 weeks
-Begin dosing one week before quit day; the target stop date should be set within the first 2 weeks of treatment, preferably in the second week.
-There should be an interval of at least 8 hours between doses.
-May be used with a nicotine transdermal system.
-If there is no effect after 12 weeks, treatment should be discontinued; longer treatment should be guided by the relative benefits and risks for the individual patient.
Use: Aid to smoking cessation treatment
What other drugs will affect bupropion?
You may have a higher risk of seizures if you use certain other medicines while taking bupropion.
Many drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with bupropion. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about bupropion
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 1464 Reviews – Add your own review/rating
- Drug class: miscellaneous antidepressants
- Bupropion Extended-Release Tablets
- Bupropion Sustained-Release Tablets (Smoking Deterrent)
- Bupropion Tablets and Sustained-Release Tablets
- Bupropion (Advanced Reading)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about bupropion.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 20.01.
Date modified: December 03, 2017
Last reviewed: May 09, 2017