Does Praluent (alirocumab) lower triglycerides?
Does Praluent lower triglycerides?
No, Praluent (Alirocumab) has little effect on triglyceride levels.
Praluent is taken to reduce Low Density Lipoprotein cholesterol (LDL cholesterol) blood levels.
- Praluent inhibits a protein called proprotein convertase subtilisin kexin 9 (PCSK9) from binding to the LDL receptor, this ultimately results in increasing the number LDL receptors available to remove LDL from the bloodstream, therefore reduces LDL cholesterol levels.
- In the ODYSSEY OUTCOMES clinical trials for Praluent, the patients were on maximally tolerated statin doses in conjunction with Praluent. Statins are known to reduce triglycerides and LDL cholesterol, so often patients are prescribed both statins and Praluent together.
- Clinical research has shown that lowering a patient’s elevated level of total cholesterol, LDL-cholesterol, triglycerides can reduce the risk of cardiovascular disease.
Click here for a list of medications that treat high triglyceride blood levels.
References
- Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome. Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242174/
- Praluent Medication Information: https://www.drugs.com/pro/praluent.html
Read next
Praluent vs Repatha: What's the difference?
The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, number of treatment indications, dosage forms available and number of strengths available in syringe and pens forms. Continue reading
What are PCSK9 Inhibitors and how do they work?
The PCSK9 inhibitors are used for the treatment of high-risk patients with elevated cholesterol, especially when statins aren't adequate. They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood. Continue reading
How does Praluent work?
Praluent works by inactivating a protein in the liver called proprotein convertase subtilisin kexin 9 (PCSK9). When Praluent inactivates PCSK9, more receptors are available to capture LDL (“bad”) cholesterol for removal from the blood. Lowering LDL in the blood can help to reduce the incidence of heart disease. Continue reading
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Drug information
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