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How long does Vivitrol last in your system?

Medically reviewed by Melisa Puckey, BPharm. Last updated on March 24, 2025.

Official Answer by Drugs.com

How long does Vivitrol last in your system? How often do I need to have Vivitrol injection?

When calculating how long Vivitrol lasts in the body, you need to consider its elimination half-life This is the time it takes for half of the drug to be metabolized and eliminated in the body. This varies from person to person with people ranging from being slower or faster at eliminating Vivitrol.

Vivitrol contains the active ingredient naltrexone which is used to reduce opiate dependence and alcohol dependence.

References

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What is low dose naltrexone (LDN)?

Low dose naltrexone means taking a dose of naltrexone that is up to one-tenth, or 10%, of the dose that is usually taken for opioid addiction. A low dose of naltrexone is approximately 4.5mg of naltrexone a day compared with the usual dosage of naltrexone for opioid addiction which is 50mg to 100mg a day. Continue reading

What happens if you drink alcohol while taking naltrexone?

Naltrexone blocks the feelings of intoxication (the “buzz”) from alcohol when you drink it. This allows people with alcohol use disorder to lessen their drinking behaviors enough to stay in treatment, avoid relapses, and take their medication. Over time, cravings for alcohol will decrease. However, naltrexone will not prevent you from becoming impaired while drinking alcohol. Do not use naltrexone so that you can drive or perform other activities under the influence of alcohol. Continue reading

What to avoid when taking naltrexone?

Do NOT take opiates, including heroin or other prescription or illegal opiates while using naltrexone. Taking opiates with naltrexone increases your risk for an overdose, coma and death. Do not use naltrexone if you are dependent on opioids or if you are experiencing opioid withdrawal symptoms. Naltrexone should not be used before you complete a medically-supervised opioid withdrawal lasting at least 7 to 14 days. Continue reading

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