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Can I take Xanax while on Vivitrol?

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 22, 2022.

Official answer


Do not take Xanax (alprazolam) while on Vivitrol (naltrexone), unless it is prescribed by a healthcare professional who is aware of your treatment for addiction.

Xanax is a benzodiazepine used to treat anxiety and panic disorders. It comes with a warning that it “exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death”. Xanax is a Schedule IV controlled substance.

A drug interaction between Xanax and Vivitrol has not been identified, but combining the two drugs may have adverse effects. It’s also not generally recommended to take a potentially habit-forming substance while being treated for alcohol or opioid dependence.

Vivitrol is an opioid antagonist used as part of a comprehensive management program that includes psychosocial support for alcoholism or addiction to opioids, such as heroin or certain painkillers. It is given by intramuscular injection about once a month. Patients must be opioid-free for 7-10 days before starting on Vivitrol.


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