Skip to main content

How long does it take Sprycel (dasatinib) to start working?

Medically reviewed by Melisa Puckey, BPharm. Last updated on March 14, 2025.

Official Answer by Drugs.com

How long do you take Sprycel for?

In the DASISION Clinical trial (NCT00481247) 54% of patients using Sprycel (dasatinib) started to show a complete cytogenetic response by 3 months, when used as a first line treatment for chronic-phase chronic myeloid leukemia.

This was compared to 31% of imatinib (Gleevec) patients having a complete cytogenetic response in the same time.

A complete cytogenetic response is when there is no Ph-positive metaphases in the bone marrow sample.

Rates of Complete Cytogenetic Response over first 9 months:

Months Sprycel (dasatinib) imatinib
3 months 54% 31%
6 months 73% 59%
9 months 78% 67%

A larger proportion of dasatinib patients reached complete cytogenetic response faster that imatinib patients.

How long do you take it for?

Sprycel is used as a long term treatment and in clinical trials has been taken for 5 years.

You usually keep on taking it as long as:

If any of these change, your health professional would discuss your options and whether you may need to discontinue treatment.

In DASISION clinical trial patients were on dasatinib or imatinib for 5 years, with the estimated 5-year overall survival being 91% for dasatinib and 90% for imatinib.

References
  • Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: https://www.nejm.org/doi/full/10.1056/NEJMoa1002315
  • Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118045/
  • Sprycel Professional Medication Information: https://www.drugs.com/pro/sprycel.html

Read next

Gleevec vs Sprycel vs Tasigna - how do they compare?

Gleevec, Sprycel and Tasigna are all prescription medicines used to treat chronic myelogenous leukemia (blood cancer). Gleevec and Sprycel are also approved for other types of cancers and tumors. These drugs are all classified as BCR-ABL kinase inhibitors and block the enzyme BCR-ABL tyrosine kinase, which is an important pathway in the development of leukemia. Continue reading

Is Sprycel a chemotherapy drug?

Sprycel (dasatinib) is an oral targeted anticancer therapy classified as a tyrosine kinase inhibitor (TKI). It used to treat some types of blood cancer, such as Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (Ph+ CML) or acute lymphoblastic leukemia (Ph+ ALL). Continue reading

Prednisone: What are 12 Things You Should Know?

Prednisone first came onto the market over sixty years ago and is still going strong. But did you know that this common drug used for a variety of different conditions also has some pretty serious side effects as well? Continue reading

See also:

Related medical questions

Drug information

Related support groups