What type of leukemia is Xospata (gilteritinib) used to treat?
Xospata (gilteritinib) is an oral treatment used to treat adult patients with relapsed or refractory acute myeloid leukemia (AML) with a FMS-like tyrosine kinase 3 (FLT3).
Xospata is the first and only FLT3-targeted therapy to be approved by the FDA for this patient population. The FLT3 mutation is detected using the FDA-approved LeukoStrat CDx FLT3 Mutation Assay, developed by Invivoscribe Technologies, Inc.
Approximately 25 to 30 percent of patients with acute myeloid leukemia have a FLT3 mutation, and it is associated with a particularly aggressive form of the disease.
Xospata inhibits multiple receptor tyrosine kinases, including FLT3. It has been shown to be effective against two FLT3 mutations, FLT3 internal tandem duplication (ITD) and FLT3 tyrosine kinase domain (TKD).
In April 2017, the FDA approved Rydapt (midostaurin) as the first targeted therapy for FLT3-mutated acute myeloid leukemia. Rydapt is indicated for the treatment of adult patients with newly diagnosed acute myeloid leukemia with the FLT3 mutation, in combination with chemotherapy (cytarabine and daunorubicin).
Read next
Prednisone: What are 12 Things You Should Know?
Prednisone first came onto the market over sixty years ago and is still going strong. But did you know that this common drug used for a variety of different conditions also has some pretty serious side effects as well? Continue reading
Anthracycline Drugs for Chemo: How Do They Work?
Anthracycline chemotherapy drugs are potent cancer treatments derived from Streptomyces bacteria. These drugs work by binding to cancer cell DNA, preventing replication and stopping tumor growth. Continue reading
How much does Blincyto (blinatumomab) cost?
The cost of a Blincyto (blinatumomab) vial is approximately $5,427 per 35 microgram (mcg) single-dose vial for injection. The overall cost for your therapy will also depend upon the length of treatment. Most people do not pay out-of-pocket for the full price of Blincyto. Continue reading
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Timolol
Timolol is used for angina, heart attack, high blood pressure, migraine, migraine prevention
Valproic acid
Valproic acid is used for bipolar disorder, cluster-tic syndrome, epilepsy, headache ...
Divalproex sodium
Divalproex sodium is used for bipolar disorder, borderline personality disorder, cyclothymic ...
Topiramate
Learn about topiramate, an anticonvulsant used for seizures, migraine prevention, and weight loss ...
Related medical questions
- What type of cancer is Daurismo (glasdegib) used to treat?
- How does Besponsa work to treat Acute Lymphoblastic Leukemia (ALL)?
- How long does methotrexate stay in your system?
- Gleevec vs Sprycel vs Tasigna - how do they compare?
- How long does it take Sprycel (dasatinib) to start working?
- Is Sprycel a chemotherapy drug?
- What is Zydelig used for and how does it work?
- How does Asparlas (calaspargase pegol-mknl) compare to Oncaspar (pegaspargase)?
- What is Idhifa used to treat?
- Is Venclexta (venetoclax) chemotherapy?
- How effective is Venclexta?
- How long do you take Venclexta for?
- How is Venclexta (venetoclax) used for AML?
- How does Venclexta work?
- What is Tibsovo used to treat?
- What is Rydapt used to treat?
Drug information
Related support groups
- Gilteritinib (1 questions, 3 members)
- Xospata (1 questions, 3 members)
- Leukemia (16 questions, 79 members)
- Acute Myeloid Leukemia (12 questions, 22 members)