How does Asparlas (calaspargase pegol-mknl) compare to Oncaspar (pegaspargase)?
Asparlas is given no more frequently than every 21 days and Oncaspar is given no more frequently than every 14 days. Oncaspar is can be given intramuscularly or intravenously while Asparlas is only given intravenously.
Asparlas (calaspargase pegol-mknl) and Oncaspar (pegaspargase) are both forms of PEGylated asparaginase indicated for use in the treatment of acute lymphoblastic leukemia (ALL).
Asparlas provides for a longer interval between doses compared to Oncaspar, and has as an extended shelf life.
Asparlas (calaspargase pegol-mknl) Injection
- FDA Approved: 2018
- Dosage Interval: Asparlas is administered intravenously no more frequently than every 21 days.
- Storage: Store in refrigerator at 2°C to 8°C (36°F to 46°F).
- Unopened vials may be stored at room temperature (15°C to 25°C [59°F to 77°F]) for no more than 48 hours.
Oncaspar (pegaspargase) Injection
- FDA Approved: 1994
- Dosage Interval: Oncaspar is administered intramuscularly or intravenously no more frequently than every 14 days.
- Storage: Store in refrigerator at 2ºC to 8ºC (36°F to 46°F).
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- Talk to your doctor about warnings, side effects, use in pregnancy and possible drug interactions with Gleevec.
- Take your Gleevec exactly as prescribed by your doctor. Do not use Gleevec if you are pregnant or planning a pregnancy.
- Take each tablet with a meal and large glass of water to help prevent stomach irritation.
- Do not use a broken Gleevec tablet. The medicine from a broken pill can be dangerous if it gets in your mouth, eyes, or nose, or on your skin.
- Do not use grapefruit products while taking Gleevec, unless okayed by your healthcare provider
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Is there a generic for Gleevec?
Yes, there is a generic version of Gleevec known as imatinib. Imatinib comes in a 100-mg and 400-mg oral tablet. Generic imatinib was approved in the U.S. in Dec. 2015 and was first manufactured by Sun Pharmaceuticals. Today, there are multiple manufacturers that produce the generic version of Gleevec. Imkeldi, an oral solution of imatinib first approved in November 2024, does not yet have a generic option. Continue reading
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