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How does Asparlas (calaspargase pegol-mknl) compare to Oncaspar (pegaspargase)?

Medically reviewed by Judith Stewart, BPharm. Last updated on March 19, 2025.

Official Answer by Drugs.com

Asparlas is given no more frequently than every 21 days and Oncaspar is given no more frequently than every 14 days. Oncaspar is can be given intramuscularly or intravenously while Asparlas is only given intravenously.

Asparlas (calaspargase pegol-mknl) and Oncaspar (pegaspargase) are both forms of PEGylated asparaginase indicated for use in the treatment of acute lymphoblastic leukemia (ALL).

Asparlas provides for a longer interval between doses compared to Oncaspar, and has as an extended shelf life.

Asparlas (calaspargase pegol-mknl) Injection

Oncaspar (pegaspargase) Injection

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