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Generic name: calaspargase pegolkal-AS-par-jase-PEG-ol ]
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Oct 19, 2022. Written by Cerner Multum.

What is Asparlas?

Asparlas is used to treat acute lymphoblastic leukemia in children and young adults from 1 month to 21 years old.

Asparlas may also be used for purposes not listed in this medication guide.


You should not use Asparlas if you have ever received pegaspargase and it caused an allergic reaction, a blood clot, pancreatitis, bleeding, or liver problems.

Before taking this medicine

You should not use Asparlas if you are allergic to it, or if:

  • you have liver disease;

  • you have had a serious allergic reaction to pegaspargase; or

  • you have had a blood clot, pancreatitis, or serious bleeding caused by using asparaginase.

Tell your doctor if you have ever had:

  • pancreatitis;

  • heart problems;

  • a blood clot; or

  • liver disease.

Asparlas may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

Asparlas may interact with birth control pills. To prevent pregnancy while using this medicine, use an effective non-oral form of birth control (injection, implant, skin patch, vaginal ring) plus a barrier form of birth control (condom, diaphragm, cervical cap, contraceptive sponge).

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How should I take Asparlas?

Asparlas is given as an infusion into a vein. A healthcare provider will give you this injection.

Asparlas is usually given once every 21 days. Your doctor will determine how long to treat you with Asparlas.

Asparlas doses are based on body surface area (height and weight). Your dose needs may change if you gain or lose weight or if you are still growing.

You will need frequent medical tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Asparlas.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Asparlas?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Asparlas side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, redness; feeling light-headed; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

You will be watched closely for at least 1 hour after each injection, to make sure you do not have an allergic reaction.

Asparlas may cause serious side effects. Call your doctor at once if you have:

  • easy bruising, unusual bleeding;

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting;

  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or

  • signs of a blood clot--headache, sudden numbness or weakness, blurred vision, chest pain, swelling or redness in an arm or leg.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Asparlas may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Asparlas?

Other drugs may affect Asparlas, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.