Asparlas Side Effects

Generic name: calaspargase pegol

Medically reviewed by Drugs.com. Last updated on Dec 29, 2024.

Note: This document provides detailed information about Asparlas.

Applies to calaspargase pegol: intravenous solution Side Effects associated with calaspargase pegol. Some dosage forms listed on this page may not apply specifically to the brand name Asparlas.

Applies to calaspargase pegol: intravenous solution.

Precautions

It is very important that your doctor check your or your child's progress closely while receiving this medicine to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (eg, condoms, spermicide) along with your pills during treatment and for at least 3 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Check with your doctor right away if you have loss of appetite, nausea, or pains in stomach, side, or abdomen, possibly radiating to the back. These could be symptoms of pancreatitis (swelling of the pancreas).

This medicine may increase your risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Serious side effects of Asparlas

Along with its needed effects, calaspargase pegol (the active ingredient contained in Asparlas) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking calaspargase pegol:

Other side effects of Asparlas

Some side effects of calaspargase pegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to calaspargase pegol: intravenous solution.

Hematologic adverse events

• Very common (10% or more): Abnormal clotting (e.g., activated partial thromboplastin time prolonged, blood fibrinogen decreased; diarrhea: colitis, diarrhea, enterocolitis, neutropenic colitis) (14%)
• Common (1% to 10%): Embolic/thrombotic events (e.g., device related thrombosis, disseminated intravascular coagulation, embolism, intracardiac thrombus, intracranial venous sinus thrombosis, pulmonary embolism, superior sagittal sinus thrombosis, thrombosis in device, venous thrombosis, venous thrombosis limb), hemorrhage (e.g., disseminated intravascular coagulation, epistaxis, hematoma, hemorrhage intracranial, melena, esophageal ulcer hemorrhage, small intestinal hemorrhage, upper GI hemorrhage)^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity^[Ref]

Immunologic

• Common (1% to 10%): Sepsis (e.g., bacterial sepsis, sepsis), fungal infection (e.g., fungal infection, hepatic infection fungal, respiratory tract infection fungal, splenic infection fungal, systemic candida)
• Frequency not reported: Immunogenicity^[Ref]

Hepatic

• Very common (10% or more): Elevated transaminase (e.g., alanine aminotransferase increased, aspartate aminotransferase increased, transaminases increased) (52%), bilirubin increased (e.g., bilirubin conjugated increased, blood bilirubin increased) (20%)^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea (e.g., hypoxia, respiratory failure), pneumonia (e.g., lung infection, pneumonia, pneumonitis)^[Ref]

Cardiovascular

• Common (1% to 10%): Arrhythmia (e.g., atrioventricular block complete, sinus tachycardia, ventricular arrhythmia), cardiac failure (e.g., ejection fraction decreased, left ventricular dysfunction)^[Ref]

Gastrointestinal

• Very common (10% or more): Pancreatitis (e.g., amylase increased, lipase increased, pancreatic necrosis, pancreatitis, pancreatitis relapsing) (18%)
• Common (1% to 10%): Diarrhea^[Ref]

See also:

Frequently asked questions

• How does Asparlas (calaspargase pegol-mknl) compare to Oncaspar (pegaspargase)?

Further information

Asparlas side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer