Asparlas Side Effects

Generic name: calaspargase pegol

Medically reviewed by Drugs.com. Last updated on Nov 19, 2023.

Note: This document contains side effect information about calaspargase pegol. Some dosage forms listed on this page may not apply to the brand name Asparlas.

Applies to calaspargase pegol: intravenous solution.

Serious side effects of Asparlas

Along with its needed effects, calaspargase pegol (the active ingredient contained in Asparlas) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking calaspargase pegol:

More common

Bloating
chills
constipation
dark urine
difficulty breathing
fast heartbeat
fever
indigestion
loss of appetite
nausea
pain in the chest, groin, or legs, especially the calves
pains in the stomach, side, or abdomen, possibly radiating to the back
severe, sudden headache
slurred speech
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
vision changes
vomiting
yellow eyes or skin

Less common

Bleeding gums
chest pain or discomfort
confusion
cough
coughing up blood
difficulty in swallowing
dilated neck veins
dizziness
extreme tiredness or weakness
fainting
slow or irregular heartbeat
headache
increased menstrual flow or vaginal bleeding
itching in the genital or other skin areas
lightheadedness
nosebleeds
paralysis
prolonged bleeding from cuts
rapid, shallow breathing
red or black, tarry stools
red or dark brown urine
scaling of the skin
sneezing
sore throat
swelling of the face, fingers, feet, or lower legs
tightness in the chest
weight gain

Other side effects of Asparlas

Some side effects of calaspargase pegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

For Healthcare Professionals

Applies to calaspargase pegol: intravenous solution.

Hematologic

Very common (10% or more): Abnormal clotting (e.g., activated partial thromboplastin time prolonged, blood fibrinogen decreased; diarrhea: colitis, diarrhea, enterocolitis, neutropenic colitis) (14%)

Common (1% to 10%): Embolic/thrombotic events (e.g., device related thrombosis, disseminated intravascular coagulation, embolism, intracardiac thrombus, intracranial venous sinus thrombosis, pulmonary embolism, superior sagittal sinus thrombosis, thrombosis in device, venous thrombosis, venous thrombosis limb), hemorrhage (e.g., disseminated intravascular coagulation, epistaxis, hematoma, hemorrhage intracranial, melena, esophageal ulcer hemorrhage, small intestinal hemorrhage, upper GI hemorrhage)^[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity^[Ref]

Immunologic

Common (1% to 10%): Sepsis (e.g., bacterial sepsis, sepsis), fungal infection (e.g., fungal infection, hepatic infection fungal, respiratory tract infection fungal, splenic infection fungal, systemic candida)

Frequency not reported: Immunogenicity^[Ref]

Hepatic

Very common (10% or more): Elevated transaminase (e.g., alanine aminotransferase increased, aspartate aminotransferase increased, transaminases increased) (52%), bilirubin increased (e.g., bilirubin conjugated increased, blood bilirubin increased) (20%)^[Ref]

Respiratory

Common (1% to 10%): Dyspnea (e.g., hypoxia, respiratory failure), pneumonia (e.g., lung infection, pneumonia, pneumonitis)^[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia (e.g., atrioventricular block complete, sinus tachycardia, ventricular arrhythmia), cardiac failure (e.g., ejection fraction decreased, left ventricular dysfunction)^[Ref]

Gastrointestinal

Very common (10% or more): Pancreatitis (e.g., amylase increased, lipase increased, pancreatic necrosis, pancreatitis, pancreatitis relapsing) (18%)

Common (1% to 10%): Diarrhea^[Ref]