Medically reviewed by Drugs.com. Last updated on July 1, 2020.
Generic name: CALASPARGASE PEGOL 750U in 1mL
Dosage form: injection, solution
The recommended dose of ASPARLAS is 2,500 units/m2 given intravenously no more frequently than every 21 days.
Monitor patients at least weekly, with bilirubin, transaminases, glucose and clinical examinations until recovery from the cycle of therapy. If an adverse reaction should occur, modify treatment according to Table 1.
|Infusion Reaction or Hypersensitivity Reaction||Grade 1||
|Grade 3 to 4||
|Hemorrhage||Grade 3 to 4||
|Pancreatitis||Grades 3 to 4||
|Thromboembolism||Uncomplicated deep vein thrombosis||
|Severe or life-threatening thrombosis||
|Hepatotoxicity||Total bilirubin more than 3 times to no more than 10 times the upper limit of normal||
|Total bilirubin more than 10 times the upper limit of normal||
Preparation and Administration
ASPARLAS is a clear and colorless solution. Visually inspect parenteral drug products for particulate matter, cloudiness, or discoloration prior to administration. If any of these are present, discard the vial. Do not administer if ASPARLAS has been shaken or vigorously agitated, frozen, or stored at room temperature for more than 48 hours.
- Dilute ASPARLAS in 100 mL of 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP using sterile/aseptic technique. Discard any unused portion left in a vial.
- After dilution, administer immediately into a running infusion of either 0.9% sodium chloride or 5% dextrose, respectively.
- Administer the dose over a period of 1 hour.
- Do not infuse other drugs through the same intravenous line during administration of ASPARLAS.
- The diluted solution may be stored for up to 4 hours at room temperature (15°C to 25°C [59°F to 77°F]) or refrigerated at 2°C to 8°C (36°F to 46°F) for up to 24 hours.
- Protect from light. Do not shake or freeze.
Frequently asked questions
More about Asparlas (calaspargase pegol)
- Side Effects
- During Pregnancy
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: miscellaneous antineoplastics
- FDA Approval History
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