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User Reviews for Mercaptopurine

Also known as: Purixan, Purinethol

Mercaptopurine has an average rating of 6.2 out of 10 from a total of 29 ratings on 48% of those users who reviewed Mercaptopurine reported a positive effect, while 31% reported a negative effect.

Condition Avg. Rating Reviews Compare
Autoimmune Hepatitis  Off-label 9.0
4 reviews 2 medications
Ulcerative Colitis, Maintenance  Off-label 6.6
8 reviews 20 medications
Crohn's Disease, Acute  Off-label 5.5
4 reviews 32 medications
Crohn's Disease, Maintenance  Off-label 5.3
13 reviews 26 medications
Summary of Mercaptopurine reviews 6.2 29 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Mercaptopurine

Jess · Taken for 1 to 6 months March 3, 2021

For Ulcerative Colitis, Maintenance: “6MP is the first drug that’s put me into remission and it’s been a long long time since I’ve been in remission. I take it alongside Octasa too. I still get some UC symptoms now and again but for the first time in so long I feel normal! However, I have had a huge amount of hair loss. Probably lost 1/3 of the hair on my head and because of this I’m being moved onto Humira. I hope this new drug stops my hair loss and keeps me in remission!”

5 / 10
Amy · Taken for 10 years or more July 24, 2020

For Ulcerative Colitis, Maintenance: “Started 6mp (mercaptopurine) after spending almost 2 years on prednisone for my chronic ulcerative colitis . The first year was the toughest, chronic nausea but so worth it in the end. Been healthy and in remission for 14 years. Unfortunate, was taking 75mg but it’s now showing that my liver isn’t properly metabolizing the drug even tho my liver enzymes are normal!!! It’s unreal that now I’m taking 50mg and showing signs of slowly working toward a flare up. Chronic belly pain. I would stay on this forever if I can. Petrified to try anything else. Would recommend this drug to anyone with moderate to severe UC!! I also have pancolitis so that means my entire colon is bad. And this drug works!!”

10 / 10
Brent · Taken for 10 years or more July 20, 2020

For Crohn's Disease, Maintenance: “I’ve been on Mercaptopurine (50mg 4 days a week, 25mg the other 3) with 100mg Allopurinol for almost 15 years. I’m asymptomatic and always have been. Crohns not detectable in blood work, zero pain, can eat anything and I run ultra marathons (lucky I know). Have had gasterctomy and months in hospital and don’t want that again. I’m scoped every 2 years and I have no crohns in me. Have zero side effects. They tried me on Aziothroprine(?) but it made me vomit so much I was hospitalised. It’s old-school, hard-core but works well for me.”

10 / 10
Jodie March 31, 2020

For Crohn's Disease, Acute: “In my opinion, I have had Crohn’s far longer but was only officially diagnosed last year. My treatment started with Prednisone for a few months before tapering it down and adding 6-Mercaptopurine (6MP) with 10mg of prednisone. After being on it for less than a month I had a terrible flare up and ended up in the hospital. While there they did not give me the 6MP and I was dealing with horrible acid reflux. After discharge I did not resume the med until seeing my Dr. 3 days later. With his approval I started taking the med again and the next night I developed excruciating pain, again all acid. I had trouble sleeping because of this. After about 6 days I had to go to the ER and I was diagnosed with medical induced pancreatitis. It was due to the 6MP and was ordered to stop it immediately. I did and 5 days later I am still not feeling great but hoping each day gets better. Looking to start Stelera.”

1 / 10
Bernice · Taken for 1 to 2 years March 15, 2020

For Crohn's Disease, Maintenance: “I have side effects of fatigue so now I take the pill at 8-9 pm. I do feel the side effects while I am asleep.”

9 / 10
Ed · Taken for 5 to 10 years March 12, 2020

For Crohn's Disease, Maintenance: “I've been on 100mg mercaptopurine per day for a good few years for maintenance of Crohn's with zero noticeable side effects. I don't feel like my immune system has weakened either. I am however only in my twenties and I surmise I will start noticing problems in the future.”

10 / 10
Chronsmom · Taken for 1 to 6 months July 21, 2019

For Crohn's Disease, Maintenance: “My son was on mercaptopurine at age 14 and had a reaction so severe he ended up in the hospital for 8 days. A blood vessel behind his eye broke so his vision was impaired. He had heart palpitations & trouble breathing. His platelets were dangerously low. He had to have 3 blood transfusions. We almost lost him. I know people who have been on this med for years with no problems. I am just sharing this to let others know to be extremely careful & if something doesn't seem right, contact your doctor immediately! There are no stupid questions, seriously. Always better to be safe than sorry.”

1 / 10
sid June 12, 2019

For Ulcerative Colitis, Maintenance: “Developed UC at 51 years old. Hospitalized. IV steroids 6 hourly 10 days, prescribed on Mesalazine while reducing prednisone. I had to stop Mesalazine. Started on Aza and made me very ill, vomiting. Swapped to 6mercaptopurine (6MP) and tolerated this well. Joints ached but built up stamina again and ok. 2 months in and thumbs and index fingers started going numb. Advised I have to stop because of peripheral neuropathy from 6MP. Awaiting next course of action”

7 / 10
COLLEGE STUDENT · Taken for 5 to 10 years March 5, 2019

For Crohn's Disease, Maintenance: “I have been on mercaptopurine since 2010. I was put on this medicine after I was first diagnosed with Crohn's and had a bowel resection. I have taken this medicine for 9 years without any problems. I am now at a point where it is no longer working and they are putting me on a new prescription.”

9 / 10
Jet1111 · Taken for 5 to 10 years January 27, 2019

For Ulcerative Colitis, Maintenance: “This med put me in remission after my first terrible flare (while weaning off prednisone). It has kept me in remission since (7 years), although I do have some mini flares from time to time, suggesting that there is probably still some inflammation in my colon. The higher dose did not agree with my blood work, so I remain on a moderate dose. I also take Lialda for my left sided UC and VSL3 probiotic. 6mp has given me my life back. I go for blood work often (must be done while on this med) monitoring blood counts, liver function, etc. So far, my body responds very well to this med, with no side effects. From what I’ve been told, you will know early on whether 6mp is right for you. It has a very low side effect profile (especially compared with biologics) and has been around for a long time (since about 1957), and long term use stats look good.”

10 / 10
desert flower · Taken for 1 to 6 months January 1, 2019

For Crohn's Disease, Acute: “This medication attacked my joints. It would go from my neck one day and to my elbow the next day and to my wrists and fingers another day. It was so painful and it took about 18 months for the pain I was experiencing to subside but left me with arthritis in my wrist and thumb. I did call my GI Dr. and told him I was experiencing excruciating pain. He told me to keep taking the medication. I took it for over a month and decided the Dr. didn't care about me so I stopped taking it. Worst experience with a Dr. and drug reaction I've ever had in my 70 years on earth. This was in Sept of 2010.”

1 / 10
anonymous · Taken for 5 to 10 years April 29, 2018

For Ulcerative Colitis, Maintenance: “I have been on mercaptopurine for about 6+ years and, thankfully, have had no side effects. I have been in remission (UC) since on this medication”

10 / 10
tinyyoki August 6, 2017

For Crohn's Disease, Maintenance: “This drug is a nightmare!!! Total fatigue with breathlessness, Arm weakness and numbness, nausea, light headedness. Now have developed tinnitus which is a constant pulsation through ears and head. My white blood cells have dropped dangerously low and my red blood cells are really poor. I am naturally now off the drug but don't know how long till I get back to health. ONLY GO ON THIS DRUG AS A LAST RESORT>”

1 / 10
Jo23 February 17, 2017

For Crohn's Disease, Maintenance: “This medicine will make you feel like you been hit by a car everyday, exhausted, plus your liver and pancreas take a massive hit. I had constant pain and all my crohns complaints returned, I was fine on prednisone and entocort but my doctor wanted to make it even better.. please pay EXTREME CAUTION using this medicine before ending up in the hospital. I'm not saying this medicine is bad but for one person it seems extremely well or extremely bad, in my case the worst time I ever been through. Pay attention!”

1 / 10
Anonymous February 14, 2017

For Crohn's Disease, Maintenance: “I've been on this medicine for 2 months. I feel, most days like I've been in a car accident. The pain is very difficult to handle. I ache like I have the flu. Thinking about not taking good it and take my chances. What could be worse?”

5 / 10
Jndebar · Taken for 1 to 6 months October 29, 2016

For Crohn's Disease, Maintenance: “I've been using this drug for just over a month and everything seems like it's going down hill. This drug will make me extremely tired but also keep me awake. It's too inconsistent for my body. It should be helping with bodily functions and minimize pain but it does quite the opposite. Some days my body can't move very fast because of the pain. And if it's not the pain it's fatigue all day. I've had the same problem with other drugs like this. There has to be a way to help without all of the drugs or surgeries.”

1 / 10
Anonymous · Taken for 6 months to 1 year May 4, 2016

For Ulcerative Colitis, Maintenance: “It seems to "control" the UC symptoms, but it has wreaked havoc with my skin and hair. I have lost so much hair, and what doesn't fall out, doesn't grow either. Skin was peppered with little red "spots" that, when they go away, leave brown spots. I itch. I am nearly 80, have never been on any medication and I think my body "knows" how foreign this is.”

5 / 10
Francescaphilip · Taken for 2 to 5 years September 3, 2014

For Ulcerative Colitis, Maintenance: “Mercaptopurine has certainly helped me with my ulcerative colitis but the side effects of a lowered immune system has been a debilitating blow to me. I catch every influenza infection that comes along, to the point that I am now taking asthmatic sprays to help me with my breathing and coughing. I have been getting bad mouth infections and generally my immune resistance has plummeted. I also have been getting heart palpitations and am now on the medicine Betaloc to try and rectify this problem. I need to tell you that before taking Metcaptopurine I hardly ever got a cold or the flu. I am in my sixties, I am employed, lead a busy life but I also know that the side effects of taking Mercaptopurine has given me other negative health issues.”

5 / 10
POConnor August 3, 2014

For Autoimmune Hepatitis: “I was diagnosed with Autoimmune Hepatitis in Nov of 2013. I was prescribed IMURAN as well as Prednisone. I was unable to take the IMURAN due to side effect of violent vomiting. I was prescribed Mercaptopurine and within 1 week became stable and have improved weekly. Seven months later, I now take only the Mercaptopurine and my enzymes have stayed stabilized.”

10 / 10
Bitternwatcher · Taken for 1 to 6 months January 26, 2014

Purinethol (mercaptopurine) for Autoimmune Hepatitis: “On azathioprine for 6 months but it suppressed my bone marrow and my platelet levels fell dangerously low. The azathioprine dose was reduced but my liver readings shot up. Was put on mercaptopurine 2 months ago and since then all levels have returned to normal.”

10 / 10
Mbsunny December 1, 2013

For Autoimmune Hepatitis: “I have been on 50mgs daily since Sept 2012 to date. No side effects at all. I'm in the process of my prednisone wean and hope to also get off mercaptopurine by Spring if 2014.”

10 / 10
Kielbasahead · Taken for 5 to 10 years July 3, 2013

For Crohn's Disease, Maintenance: “I have been on this medication for 5 years since a bowel resection and have not had any pain nor side effects. The doctor monitors my blood counts every 3 months for low platelets; but all has been good. I”

10 / 10
vldev February 6, 2013

For Crohn's Disease, Maintenance: “I have been on this medication for maintenance for at least 20 years. I have not had a bleeding episode since I started. Also, I have experienced no side effects. I don't know how others would tolerate it, but for me it really has worked. I have had Crohn's Disease over 40 years.”

10 / 10
michael1974 · Taken for less than 1 month January 19, 2013

For Crohn's Disease, Maintenance: “I have been on this medicine for a week. I have no energy and I only sleep about 4 hours a night. I can fall asleep but can't stay asleep. I think I am going to ask my doctor to switch me to something else. I can't focus very well with this medicine. ”

1 / 10
Mbsunny54 · Taken for less than 1 month September 19, 2012

For Autoimmune Hepatitis: “Only been using this for 3 weeks. Started mercaptopurine Aug 30th at 25mgs daily for 2 weeks. Went up to 50mgs daily Sep14th. I take it at bedtime. Some body aches, dizziness, abdominal bloating. Blood work every 2 weeks. Will rate this medicine again in a couple of weeks.”

6 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.