How long does it take Sprycel (dasatinib) to start working?
How long do you take Sprycel for?
In the DASISION Clinical trial (NCT00481247) 54% of patients using Sprycel (dasatinib) started to show a complete cytogenetic response by 3 months, when used as a first line treatment for chronic-phase chronic myeloid leukemia.
This was compared to 31% of imatinib (Gleevec) patients having a complete cytogenetic response in the same time.
A complete cytogenetic response is when there is no Ph-positive metaphases in the bone marrow sample.
Rates of Complete Cytogenetic Response over first 9 months:
| Months | Sprycel (dasatinib) | imatinib |
| 3 months | 54% | 31% |
| 6 months | 73% | 59% |
| 9 months | 78% | 67% |
A larger proportion of dasatinib patients reached complete cytogenetic response faster that imatinib patients.
How long do you take it for?
Sprycel is used as a long term treatment and in clinical trials has been taken for 5 years.
You usually keep on taking it as long as:
- your tests show it is working well
- your condition has not worsened
- you are not having severe side effects.
If any of these change, your health professional would discuss your options and whether you may need to discontinue treatment.
In DASISION clinical trial patients were on dasatinib or imatinib for 5 years, with the estimated 5-year overall survival being 91% for dasatinib and 90% for imatinib.
References
- Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: https://www.nejm.org/doi/full/10.1056/NEJMoa1002315
- Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118045/
- Sprycel Professional Medication Information: https://www.drugs.com/pro/sprycel.html
Read next
Gleevec vs Sprycel vs Tasigna - how do they compare?
Gleevec, Sprycel and Tasigna are all prescription medicines used to treat chronic myelogenous leukemia (blood cancer). Gleevec and Sprycel are also approved for other types of cancers and tumors. These drugs are all classified as BCR-ABL kinase inhibitors and block the enzyme BCR-ABL tyrosine kinase, which is an important pathway in the development of leukemia. Continue reading
Is Sprycel a chemotherapy drug?
Sprycel (dasatinib) is an oral targeted anticancer therapy classified as a tyrosine kinase inhibitor (TKI). It used to treat some types of blood cancer, such as Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (Ph+ CML) or acute lymphoblastic leukemia (Ph+ ALL). Continue reading
What is CAR T-cell therapy and how does it work?
CAR T-cell therapy is a personalized treatment that uses a patient's own immune cells to fight certain cancers and autoimmune diseases. By harnessing and reprogramming a patient’s own immune cells, this therapy offers a new option for those who have not responded to conventional treatments.
Continue readingSee also:
Related medical questions
- How does Besponsa work to treat Acute Lymphoblastic Leukemia (ALL)?
- What is the lifetime or cumulative dose for Adriamycin?
- What to avoid when taking Gleevec?
- How much does Blincyto (blinatumomab) cost?
- Is there a generic for Gleevec?
- How much does Tecartus cost?
- How does Gleevec (imatinib) work?
- What is the cost of Kymriah?
- Is Tasigna a form of chemotherapy?
- Is Tecartus a one-time treatment?
- Is Blincyto (blinatumomab) chemotherapy?
- How does Asparlas (calaspargase pegol-mknl) compare to Oncaspar (pegaspargase)?
- How is Blincyto administered?
- What is the survival rate of Kymriah?
- Can I take Gleevec while pregnant?
- How is Kymriah administered?
- What type of drug is Kymriah (tisagenlecleucel)?
- What type of cancer is Daurismo (glasdegib) used to treat?
- Prednisone: What are 12 Things You Should Know?
- How long does methotrexate stay in your system?
- Anthracycline Drugs for Chemo: How Do They Work?
- What is Zydelig used for and how does it work?
- What type of leukemia is Xospata (gilteritinib) used to treat?
Drug information
Related support groups
- Dasatinib (3 questions, 10 members)
- Sprycel (3 questions, 48 members)
- Acute Lymphoblastic Leukemia (23 questions, 15 members)
- Leukemia (16 questions, 79 members)
- Chronic Myelogenous Leukemia (CML) (15 questions, 115 members)