What is the difference between HIV treatments Symfi and Symfi Lo?
Medically reviewed by Drugs.com. Last updated on Sep 27, 2024.
Symfi vs Symfi Lo
Symfi and Symfi Lo are both three-drug combinations of efavirenz, lamivudine and tenofovir disoproxil fumarate (TDF) for the treatment of HIV-1 infection. The difference between Symfi and Symfi Lo is the amount of efavirenz contained in each product.
Symfi Lo contains a reduced dose of efavirenz (to help lower side effects) while Symfi has a dose similar to other efavirenz products already on the market.
Specifically, Symfi Lo contains a 400 mg dose of efavirenz, one-third less than the 600 mg dose of efavirenz found in Symfi. In the ENCORE1 study, 400 mg efavirenz was found to be of comparable effectiveness to 600 mg of efavirenz when combined with tenofovir and emtricitabine in adults with HIV-1 infection who had never undergone treatment.
Symfi and Symfi Lo both contain
- efavirenz (Sustiva), a non-nucleoside reverse transcriptase inhibitor
- lamivudine (Epivir), a nucleo(t)side reverse transcriptase inhibitor
- tenofovir disoproxil fumarate (Viread), a nucleo(t)side reverse transcriptase inhibitor
| Symfi | Symfi Lo | |
|---|---|---|
| FDA Approval | March 22, 2018 | February 5, 2018 |
| How Supplied |
Each tablet contains:
|
Each tablet contains:
|
| Indication |
HIV-1 Infection
|
HIV-1 Infection
|
Both Symfi and Symfi Lo are being marketed as cost-saving products from Mylan Pharmaceuticals, with list prices discounted significantly to wholesale costs of similar HIV medications on the market.
Related questions
- HIV Antiviral Drugs - What are the common side effects?
- What is the difference between HIV treatments Odefsey and Complera?
- Genvoya vs Stribild for HIV - How do they compare?
Read next
Can Descovy be used for PrEP in HIV?
Yes. The FDA approved Descovy (emtricitabine and tenofovir alafenamide) for pre-exposure prophylaxis (PrEP) in October 2019 to help reduce the risk of HIV-1 infection. Continue reading
Modafinil (Provigil) vs Adderall: What's the difference?
Modafinil and Adderall are both classified as CNS stimulants but have different chemical structures, which means there are differences in their addiction potential and risk of side effects. Modafinil and Adderall both have stimulant-type effects, but modafinil is a much milder stimulant than Adderall.
Continue reading
Which medicines should not be taken with Biktarvy?
- Biktarvy is a complete regimen and use with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
- Biktarvy is associated with many drug interactions as it contains three different medicines, increasing your risk for interactions. Have your health care provider check for possible interactions with other prescription medicines, OTCs or herbal you take.
- You should not take Biktarvy with dofetilide (Tikosyn), a drug used for heart rhythm disorders or rifampin (Rifadin), a medicine for tuberculosis (TB). These drugs are contraindicated with the use of Biktarvy.
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Cabenuva
Cabenuva (cabotegravir and rilpivirine) injections are a long-acting HIV treatment used to keep HIV ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Timolol
Timolol is used for angina, heart attack, high blood pressure, migraine, migraine prevention
Valproic acid
Valproic acid is used for bipolar disorder, cluster-tic syndrome, epilepsy, headache ...
Divalproex sodium
Divalproex sodium is used for bipolar disorder, borderline personality disorder, cyclothymic ...
Related medical questions
- How much does HIV treatment Cimduo cost?
- What drugs are contained in the HIV treatment Delstrigo?
- What drugs are contained in the HIV treatment Cimduo?
- What drugs are contained in the HIV treatment Symfi Lo?
- How do you increase your CD4 count?
- What is an undetectable HIV viral load?
- Who are the actors in the Dovato commercial?
- Descovy vs Truvada: How do they compare for HIV / PrEP?
- What do I need to know about Drug Interactions?
- What if I miss a dose of Biktarvy?
- Who are the actors in the Biktarvy commercials?
- How fast or how long does it take Biktarvy to work?
- Do you have to take Biktarvy forever?
- Does Dovato cause kidney damage?
- Does Dovato cause weight gain?
- What are 9 key Dovato side effects to watch out for?
- Can I drink alcohol while taking Biktarvy?
- Is Biktarvy covered by insurance?
- How effective is Dovato for HIV?
- What is the generic name for Biktarvy?
- What is Biktarvy used for?
- Apretude vs Descovy: How do they compare?
- Who are the actors in the Descovy commercial?
- Apretude vs Cabenuva, what is the difference?
- Does Biktarvy cause hair loss?
- What is the difference between Biktarvy and Descovy?
- What is the difference between Vemlidy and Viread?
- Can you crush Biktarvy tablets?
- Does Biktarvy increase cholesterol?
- Who is eligible for the Biktarvy Copay Card?
Related support groups
- Tenofovir (8 questions, 14 members)
- Lamivudine (6 questions, 7 members)
- Atripla (3 questions, 60 members)
- Efavirenz (2 questions, 6 members)
- Symfi Lo (2 questions, 3 members)
- Lamivudine/tenofovir (2 questions, 3 members)
- Symfi (2 questions, 3 members)
- Efavirenz/lamivudine/tenofovir (2 questions, 3 members)
- HIV Infection (99 questions, 250 members)