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What is the difference between HIV treatments Symfi and Symfi Lo?

Symfi vs Symfi Lo

Medically reviewed by Last updated on Oct 7, 2019.

Official Answer


Symfi and Symfi Lo are both three-drug combinations of efavirenzlamivudine and tenofovir disoproxil fumarate (TDF) for the treatment of HIV-1 infection. The difference between Symfi and Symfi Lo is the amount of efavirenz contained in each product.

Symfi Lo contains a reduced dose of efavirenz (to help lower side effects) while Symfi has a dose similar to other efavirenz products already on the market.

Specifically, Symfi Lo contains a 400 mg dose of efavirenz, one-third less than the 600 mg dose of efavirenz found in Symfi. In the ENCORE1 study, 400 mg efavirenz was found to be of comparable effectiveness to 600 mg of efavirenz when combined with tenofovir and emtricitabine in adults with HIV-1 infection who had never undergone treatment.

Symfi and Symfi Lo both contain

  Symfi Symfi Lo
FDA Approval March 22, 2018 February 5, 2018
How Supplied

Each tablet contains:

  • efavirenz 600 mg
  • lamivudine 300 mg
  • tenofovir disoproxil fumarate and 300 mg

Each tablet contains:

  • efavirenz 400 mg
  • lamivudine 300 mg
  • tenofovir disoproxil fumarate 300 mg

HIV-1 Infection

  • in adult and pediatric patients weighing at least 40 kg.
HIV-1 Infection
  • in adult and pediatric patients weighing at least 35 kg.

Both Symfi and Symfi Lo are being marketed as cost-saving products from Mylan Pharmaceuticals, with list prices discounted significantly to wholesale costs of similar HIV medications on the market. 

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