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Clobex Spray, Lotion & Shampoo - Which one do I use?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 30, 2020.

Official Answer

by Drugs.com

Key Points

  • Clobex Spray 0.05% and Clobex Shampoo 0.05% are both topical corticosteroid medicines used to treat psoriasis.
  • Clobex Lotion 0.05% is also approved to treat psoriasis, as well as the swelling and itching due to other skin conditions such as eczema.
  • Clobex topical treatments are used only in patients 18 years of age or older.

Clobex (clobetasol propionate) 0.05% is a super-high potent topical corticosteroid available as a prescription spray, lotion and shampoo. Clobex Spray is used to treat plaque psoriasis on the skin and Clobex Shampoo treats scalp psoriasis. Clobex Lotion is approved to treat the swelling and itching due to certain skin conditions such as atopic dermatitis (eczema) and plaque psoriasis.

Lotions and sprays are often more acceptable for use on the skin and hard-to-reach areas, while shampoos work well on the scalp.

How do I use Clobex?

Always follow your doctor’s directions for dosing and length of time to treat your skin or scalp condition. Do not exceed the prescribed dose as it may increase the risk for severe side effects. Read the patient medication guide each time you get a prescription. If you have questions, ask your doctor or pharmacist.

Clobex Spray 0.05% is approved to treat moderate to severe plaque psoriasis affecting up to 20% of your body surface area (BSA).

  • The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day.
  • Treatment should be limited to 4 consecutive weeks. Use Clobex Spray for the shortest amount of time needed to clear your skin condition.
  • Do not use Clobex Spray on the face, axillae (underarm area), or groin area; or if there is atrophy (skin thinning) at the treatment site. Do not use Clobex Spray to treat rosacea or perioral dermatitis.

Clobex Lotion 0.05% is used for certain skin conditions such as atopic dermatitis and psoriasis (known as corticosteroid-responsive dermatoses).

  • You should not apply more than 50 mL (1.75 fluid ounces) of Clobex Lotion to your skin per week.
  • Clobex Lotion should not be used for more than 2 weeks in a row unless your doctor tells you to use it for a longer time. Clobex Lotion should only be used for the shortest amount of time needed to treat your skin condition.
  • Do not use Clobex Lotion on the face, axillae (underarm area), or groin area; or if there is atrophy (skin thinning) at the treatment site. Do not use Clobex Spray to treat rosacea or perioral dermatitis.

Clobex Shampoo 0.05% is used to treat moderate to severe forms of scalp psoriasis.

  • You should not apply more than 50 mL (1.75 fluid ounces) of Clobex Shampoo to your scalp per week.
  • Do not use Clobex Shampoo for longer than 4 weeks unless directed by your doctor. Clobex Shampoo should only be used for the shortest period of time needed to treat your scalp psoriasis.
  • Clobex Shampoo should not be used on your face, groin or axillae (underarms). Do not get the medicine into your eyes or on your lips. In case of contact, rinse thoroughly with water all parts of the body that came in contact with the shampoo.

Bottom Line

Clobex Spray 0.05% is used to treat psoriasis on the skin and Clobex Shampoo 0.05% treats scalp psoriasis. Clobex Lotion 0.05% is also approved to treat psoriasis, in addition to other skin conditions such as eczema. Clobex topical treatments are used only in patients 18 years of age or older.

Always follow your doctor’s directions for dosing and length of time to treat your skin or scalp condition. Do not exceed the prescribed dose as it may increase the risk for severe side effects.

This is not all the information you need to know about Clobex (clobetasol propionate 0.05%) Topical Spray, lotion or shampoo for safe and effective use. Review the full Clobex information, and discuss this information and any questions you have with your doctor or other health care provider.

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