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Fycompa

Generic Name: perampanel (per AM pa nel)
Brand Names: Fycompa

Medically reviewed on Oct 8, 2018

What is Fycompa?

Fycompa (perampanel) is an anticonvulsant used to treat seizures in adults and children.

Fycompa is a prescription medicine that is used to treat partial-onset seizures with or without secondarily generalized seizures in patients 4 years of age and older, and for use with other medications to treat primary generalized tonic-clonic (PGTC) seizures in patients 12 years of age and older.

Fycompa may also be used for purposes not listed in this medication guide.

Important information

Some people taking Fycompa have had serious psychotic effects, especially when starting this medicine or changing doses. Stay alert to changes in your mood or symptoms.

Call your doctor right away if you have any changes in mood or behavior changes, personality changes, thoughts about suicide, or thoughts about hurting others. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Before taking this medicine

You should not use Fycompa if you are allergic to perampanel.

To make sure Fycompa is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • a history of depression or mental illness; or

  • a history of alcoholism or drug addiction.

Some people taking Fycompa have had serious psychotic effects such as anger, aggression, feeling hostile or irritable, and thoughts about hurting others. These effects may be more likely to occur when you first start taking Fycompa, or whenever your dose is changed. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

Fycompa can make certain birth control pills less effective. Ask your doctor about using non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking Fycompa.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Fycompa on the baby.

It is not known whether perampanel passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Fycompa is not approved for use by anyone younger than 12 years old.

How should I take Fycompa?

Fycompa is usually taken at bedtime. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Fycompa may be habit-forming. Never share Fycompa with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not stop using any other seizure medications suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.

Store Fycompa at room temperature away from moisture and heat. Do not allow the medicine to freeze.

Keep track of the amount of medicine used from each new bottle. Fycompa may be a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Fycompa dosing information

Usual Adult Dose of Fycompa for Seizures:

In the absence of enzyme inducing AEDs:
Initial dose: 2 mg orally once daily at bedtime. Dosage may be increased by 2 mg orally daily in increments no more frequently than every week.
Maintenance dose: 4 to 12 mg orally once daily at bedtime
Maximum dose: 12 mg orally once daily at bedtime

In the presence of enzyme inducing AEDs (including phenytoin, carbamazepine, and oxcarbazepine):
Initial dose: 4 mg orally once daily at bedtime. Patients should be monitored closely for response. Studies revealed a substantially reduced effect on seizure rates in these patients. When these enzyme-inducing AEDs are introduced or withdrawn from a treatment regimen, the patient should be monitored for clinical response and tolerability. Dose adjustment of perampanel may be necessary.
Maximum dose: 12 mg orally once daily at bedtime

Approved indication: Adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy 12 years of age and older.

Usual Pediatric Dose of Fycompa for Seizures:

Greater than or equal to 12 years of age:

In the absence of enzyme inducing AEDs: Initial dose: 2 mg orally once daily at bedtime. Dosage may be increased by 2 mg orally daily in increments no more frequently than every week. Maintenance dose: 4 to 12 mg orally once daily at bedtime Maximum dose: 12 mg orally once daily at bedtime

In the presence of enzyme inducing AEDs (including phenytoin, carbamazepine, and oxcarbazepine): Initial dose: 4 mg orally once daily at bedtime. Patients should be monitored closely for response. Studies revealed a substantially reduced effect on seizure rates in these patients. When these enzyme-inducing AEDs are introduced or withdrawn from a treatment regimen, the patient should be monitored for clinical response and tolerability. Dose adjustment of perampanel may be necessary.
Maximum dose: 12 mg orally once daily at bedtime

Approved indication: Adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy 12 years of age and older.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss your Fycompa dose for more than one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Fycompa?

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Drinking alcohol with Fycompa can cause side effects.

Fycompa side effects

Get emergency medical help if you have signs of an allergic reaction to Fycompa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Fycompa.

Stop using Fycompa and call your doctor at once if you have a side effect such as:

  • changes in mood, behavior, or personality;

  • anger, aggression, anxiety, trouble sleeping, feeling hostile or irritable;

  • talking more than usual;

  • memory problems, confusion, hallucinations;

  • unusual thoughts, paranoid behavior, panic attacks;

  • thoughts about suicide, or thoughts about hurting someone else;

  • trouble walking, loss of balance or coordination;

  • an accidental fall; or

  • severe dizziness, spinning sensation, feeling like you might pass out.

Accidental falls may occur more often in elderly patients who take Fycompa. Use caution to avoid falling or accidental injury while taking this medicine.

Common Fycompa side effects may include:

  • headache, dizziness, drowsiness;

  • feeling anxious, tired, or irritable;

  • nausea, vomiting, stomach pain;

  • bruising;

  • weight gain; or

  • loss of coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fycompa?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Fycompa with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety or depression.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • birth control pills;

  • rifampin;

  • St. John's wort;

  • other seizure medicine- carbamazepine, oxcarbazepine, phenytoin.

This list is not complete. Other drugs may interact with perampanel, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Fycompa only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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