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Phenobarbital and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with phenobarbital.


Phenobarbital Alcohol (Ethanol)

Major Drug Interaction

Ask your doctor before using PHENobarbital together with ethanol, this can add to dizziness, drowsiness and other side effects of PHENobarbital. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with PHENobarbital. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Phenobarbital High Blood Pressure (Hypertension)

Major Potential Hazard, Moderate plausibility

barbiturates IV - cardiovascular

The intravenous administration of barbiturates may produce severe cardiovascular reactions such as bradycardia, hypertension, or vasodilation with fall in blood pressure, particularly during rapid infusion. Parenteral therapy with barbiturates should be administered cautiously in patients with hypertension, hypotension, or cardiac disease. The intravenous administration of barbiturates should be reserved for emergency treatment of acute seizures or for anesthesia.


  1. (2001) "Product Information. Phenobarbital (phenobarbital)." Lilly, Eli and Company
  2. American Medical Association, Division of Drugs and Toxicology (1994) "Drug evaluations annual 1994." Chicago, IL: American Medical Association;
  3. (2001) "Product Information. Amytal Sodium (amobarbital)." Lilly, Eli and Company
  4. (2001) "Product Information. Nembutal Sodium (pentobarbital)." Abbott Pharmaceutical
  5. (2001) "Product Information. Seconal Sodium (secobarbital)." Lilly, Eli and Company
View all 5 references

Phenobarbital drug interactions

There are 785 drug interactions with phenobarbital.

Phenobarbital disease interactions

There are 15 disease interactions with phenobarbital which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.