Midazolam and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with midazolam which include:
Moderate Food Interaction
Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking midazolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take midazolam with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate Potential Hazard, High plausibility
benzodiazepines - obesity
The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.
- "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
- "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Valium (diazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Dalmane (flurazepam)." Roche Laboratories, Nutley, NJ.
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
Midazolam drug interactions
There are 479 drug interactions with midazolam
Midazolam disease interactions
There are 12 disease interactions with midazolam which include:
- acute alcohol intoxication
- closed-angle glaucoma
- respiratory depression
- prolonged hypotension
- CNS depression/electrolyte disturbances
- congestive heart failure
- renal/liver disease
- paradoxical reactions
More about midazolam
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- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Compare Alternatives
- Pricing & Coupons
- 97 Reviews
- Drug class: benzodiazepines
- Latest FDA Alerts (4)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.