Wakix Drug Interactions
Currently displaying a list of 509 drugs known to interact with Wakix (pitolisant).
- 90 major drug interactions
- 413 moderate drug interactions
- 6 minor drug interactions
Medications known to interact with Wakix
Note: Showing generic names only.
A
- abarelix
- abemaciclib
- acalabrutinib
- acetaminophen
- acrivastine
- adagrasib
- adenosine
- afatinib
- albendazole
- albuterol
- alfuzosin
- amiodarone
- amisulpride
- amitriptyline
- amoxapine
- amprenavir
- anagrelide
- apalutamide
- apomorphine
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- arsenic trioxide
- artesunate
- asciminib
- asenapine
- aspirin
- astemizole
- atazanavir
- atogepant
- atomoxetine
- avacopan
- avapritinib
- azatadine
- azithromycin
B
- bedaquiline
- belumosudil
- belzutifan
- benzgalantamine
- bepridil
- berotralstat
- betamethasone
- betrixaban
- bexagliflozin
- bicalutamide
- bisacodyl
- bitolterol
- brexpiprazole
- bromfenac
- bromocriptine
- brompheniramine
- budesonide
- buprenorphine
- bupropion
- butorphanol
C
- cabazitaxel
- cabozantinib
- capivasertib
- capmatinib
- carbamazepine
- carbinoxamine
- cariprazine
- casanthranol
- cascara sagrada
- castor oil
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- chlorcyclizine
- chloroquine
- chlorotrianisene
- chlorpheniramine
- chlorpromazine
- cilostazol
- cimetidine
- cinacalcet
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clemastine
- clofarabine
- clofazimine
- clomipramine
- clozapine
- cobicistat
- conjugated estrogens
- cortisone
- crizotinib
- cyclophosphamide
- cyproheptadine
D
- dabigatran
- dacomitinib
- daridorexant
- darifenacin
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deflazacort
- degarelix
- delavirdine
- desipramine
- desloratadine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- diclofenac
- dienestrol topical
- diflunisal
- digoxin
- dihydroergotamine
- diphenhydramine
- disopyramide
- divalproex sodium
- dofetilide
- dolasetron
- donepezil
- doxepin
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronedarone
- droperidol
- drospirenone
- duloxetine
- duvelisib
E
- edoxaban
- efavirenz
- elacestrant
- eletriptan
- eliglustat
- empagliflozin
- encorafenib
- enfortumab vedotin
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- ergonovine
- ergotamine
- eribulin
- erlotinib
- erythromycin
- escitalopram
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethinyl estradiol
- ethosuximide
- etodolac
- etonogestrel
- etoposide
- etrasimod
- ezogabine
F
- famotidine
- fedratinib
- felodipine
- fenfluramine
- fenoprofen
- fentanyl
- fexinidazole
- fexofenadine
- finerenone
- fingolimod
- flecainide
- fluconazole
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- flutamide
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- foscarnet
- fosphenytoin
- fostemsavir
- futibatinib
G
- galantamine
- ganaxolone
- gatifloxacin
- gefitinib
- gemifloxacin
- gepirone
- gilteritinib
- givinostat
- givosiran
- glasdegib
- glycerin
- glycerol phenylbutyrate
- goserelin
- granisetron
- grepafloxacin
H
- halofantrine
- haloperidol
- halothane
- histrelin
- hydrocodone
- hydrocortisone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- ibuprofen
- ibutilide
- idarubicin
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indacaterol
- indinavir
- indomethacin
- infigratinib
- inotuzumab ozogamicin
- irinotecan
- isoproterenol
- isotretinoin
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivermectin
- ivosidenib
- ixabepilone
K
L
- lactitol
- lactulose
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lenvatinib
- letermovir
- letrozole
- leuprolide
- levalbuterol
- levocetirizine
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levonorgestrel
- lisdexamfetamine
- lithium
- lofexidine
- lomefloxacin
- lonafarnib
- lonapegsomatropin
- loperamide
- loratadine
- lorlatinib
- lumateperone
- lurbinectedin
M
- macimorelin
- macitentan
- magnesium citrate
- magnesium hydroxide
- maprotiline
- maribavir
- mavacamten
- mavorixafor
- meclofenamate
- mefenamic acid
- mefloquine
- megestrol
- meloxicam
- mesoridazine
- metaproterenol
- metformin
- methadone
- methdilazine
- methotrimeprazine
- methylergonovine
- methylnaltrexone
- methylprednisolone
- methysergide maleate
- metoclopramide
- metronidazole
- mibefradil
- midazolam
- midostaurin
- mifepristone
- mineral oil
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- morphine
- moxifloxacin
- mycophenolate mofetil
- mycophenolic acid
N
- nabumetone
- naldemedine
- naproxen
- nefazodone
- nelfinavir
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nilutamide
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- norethindrone
- norfloxacin
- norgestrel
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olodaterol
- olutasidenib
- omaveloxolone
- ondansetron
- oritavancin
- osilodrostat
- osimertinib
- oxaliplatin
- oxamniquine
- oxaprozin
- oxybutynin
- oxycodone
- oxytocin
- ozanimod
P
- paliperidone
- palonosetron
- palovarotene
- panobinostat
- papaverine
- paroxetine
- pasireotide
- pazopanib
- peginterferon alfa-2b
- pemigatinib
- pentamidine
- perampanel
- perflutren
- perphenazine
- pexidartinib
- phenindamine
- phenobarbital
- phenolphthalein
- phenylbutazone
- phenytoin
- pimavanserin
- pimozide
- pirbuterol
- piroxicam
- pirtobrutinib
- polyethylene glycol 3350
- polyethylene glycol 3350 with electrolytes
- ponesimod
- posaconazole
- praziquantel
- prednisolone
- prednisone
- pretomanid
- primaquine
- primidone
- probucol
- procainamide
- prochlorperazine
- progesterone
- progesterone topical
- promazine
- promethazine
- propafenone
- propiomazine
- propofol
- propoxyphene
- protriptyline
- pyrilamine
Q
R
- raltegravir
- ranolazine
- red yeast rice
- relugolix
- repaglinide
- repotrectinib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- ripretinib
- risperidone
- ritlecitinib
- ritodrine
- rivastigmine
- rizatriptan
- roflumilast
- rolapitant
- romidepsin
- rucaparib
- ruxolitinib topical
S
- sacituzumab govitecan
- salmeterol
- saquinavir
- selegiline
- selexipag
- selpercatinib
- selumetinib
- senna
- sertraline
- sevoflurane
- sildenafil
- silodosin
- siponimod
- sirolimus protein-bound
- sodium salicylate
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- sotorasib
- sparfloxacin
- sparsentan
- st. john's wort
- stiripentol
- sulfamethoxazole
- sulindac
- sunitinib
- suzetrigine
T
- tacrine
- tacrolimus
- tamoxifen
- tazemetostat
- tecovirimat
- telavancin
- telithromycin
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terbinafine
- terbutaline
- terfenadine
- testosterone
- tetrabenazine
- thalidomide
- thioridazine
- thiotepa
- tiagabine
- ticlopidine
- tipranavir
- tirzepatide
- tizanidine
- tolmetin
- tolterodine
- toremifene
- tramadol
- trazodone
- triamcinolone
- triclabendazole
- trifluoperazine
- triflupromazine
- trimeprazine
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trofinetide
- tucatinib
U
V
- vadadustat
- valbenazine
- valproic acid
- vamorolone
- vandetanib
- vardenafil
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- viloxazine
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- vonoprazan
- voriconazole
W
Z
Wakix disease interactions
There are 4 disease interactions with Wakix (pitolisant) which include:
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- Drug class: miscellaneous central nervous system agents
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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