Phenobarbital Drug Interactions
Currently displaying a list of 803 drugs known to interact with phenobarbital.
- 241 major drug interactions
- 516 moderate drug interactions
- 46 minor drug interactions
Medications known to interact with phenobarbital
Note: Showing generic names only.
A
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acebutolol
- acetaminophen
- acetylcarbromal
- acoramidis
- acrivastine
- adagrasib
- adalimumab
- afatinib
- albendazole
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- alpelisib
- alprazolam
- altretamine
- amiloride
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anagrelide
- anakinra
- anisindione
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- apremilast
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atogepant
- atorvastatin
- atrasentan
- avacopan
- avanafil
- avapritinib
- avatrombopag
- axitinib
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- bedaquiline
- belumosudil
- benazepril
- bendamustine
- bendroflumethiazide
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- betamethasone
- betaxolol
- betrixaban
- bexagliflozin
- bexarotene
- bimekizumab
- binimetinib
- biperiden
- bisoprolol
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- cabotegravir
- cabozantinib
- calcifediol
- calcitriol
- canagliflozin
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- capmatinib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carmustine
- carvedilol
- caspofungin
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorothiazide
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cholecalciferol
- cholestyramine
- cholic acid
- cimetidine
- citalopram
- clemastine
- clevidipine
- clindamycin
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cobimetinib
- cocaine nasal
- cocaine topical
- codeine
- colesevelam
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crinecerfont
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclophosphamide
- cyclosporine
- cyproheptadine
D
- dabigatran
- dabrafenib
- daclatasvir
- dantrolene
- daprodustat
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deflazacort
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- diclofenac
- dicumarol
- dienestrol topical
- difelikefalin
- digitoxin
- dihydroergotamine
- dihydrotachysterol
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- doravirine
- doxazosin
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drospirenone
- duloxetine
- duvelisib
E
- edoxaban
- efavirenz
- elacestrant
- elagolix
- eliglustat
- elranatamab
- elvitegravir
- emapalumab
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enfortumab vedotin
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- eplerenone
- eprosartan
- eravacycline
- erdafitinib
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etonogestrel
- etoposide
- etravirine
- evening primrose
- everolimus
- exemestane
- ezogabine
F
- febuxostat
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- finerenone
- flavoxate
- flibanserin
- fluconazole
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- folic acid
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- fostemsavir
- fruquintinib
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- ginkgo
- glasdegib
- glofitamab
- glycerol phenylbutyrate
- golimumab
- granisetron
- griseofulvin
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- hemin
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydrocortisone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- ibrexafungerp
- ibrutinib
- idelalisib
- iloperidone
- imatinib
- imipramine
- indapamide
- indinavir
- indocyanine green
- infigratinib
- infliximab
- iptacopan
- irbesartan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isocarboxazid
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
- ixabepilone
- ixazomib
K
L
- l-methylfolate
- labetalol
- lacosamide
- lamotrigine
- landiolol
- lansoprazole
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- letrozole
- leucovorin
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levoleucovorin
- levomefolate calcium
- levomethadyl acetate
- levonorgestrel
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- linezolid
- liothyronine
- liotrix
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lomustine
- lonafarnib
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- lurbinectedin
M
- macimorelin
- macitentan
- maprotiline
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- mebendazole
- meclizine
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methimazole
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metronidazole
- metyrosine
- mibefradil
- midazolam
- midostaurin
- mifepristone
- minoxidil
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- momelotinib
- montelukast
- morphine
- morphine liposomal
- mosunetuzumab
- multivitamin, prenatal
N
- nabilone
- nadolol
- nalbuphine
- naldemedine
- naloxegol
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- neratinib
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
- norethindrone
- norgestrel
- nortriptyline
O
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- ospemifene
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxycodone
- oxymorphone
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- paliperidone
- palovarotene
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paricalcitol
- paroxetine
- pazopanib
- pemigatinib
- pemoline
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimavanserin
- pimozide
- pindolol
- pioglitazone
- pirtobrutinib
- pitolisant
- polatuzumab vedotin
- polythiazide
- pomalidomide
- ponatinib
- ponesimod
- posaconazole
- pralsetinib
- pramipexole
- pramoxine topical
- praziquantel
- prazosin
- prednisolone
- prednisone
- pregabalin
- pretomanid
- prilocaine
- primidone
- procaine
- procaine penicillin
- procarbazine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- propafenone
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyridoxine
- pyrilamine
Q
R
- raltegravir
- ramelteon
- ramipril
- ranolazine
- rasagiline
- regorafenib
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- revumenib
- ribociclib
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- risperidone
- ritlecitinib
- ritonavir
- rivaroxaban
- roflumilast
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
S
- sacituzumab govitecan
- safinamide
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- seladelpar
- selegiline
- selinexor
- selpercatinib
- selumetinib
- sertraline
- sibutramine
- sildenafil
- silodosin
- siltuximab
- silver nitrate topical
- silver sulfadiazine topical
- simeprevir
- siponimod
- sirolimus
- sirolimus protein-bound
- sodium nitrite
- sodium oxybate
- sodium phenylbutyrate
- sofosbuvir
- solifenacin
- sonidegib
- sorafenib
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfasalazine
- sunitinib
- suvorexant
- suzetrigine
T
- tacrolimus
- tadalafil
- talquetamab
- tamoxifen
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- teclistamab
- telaprevir
- telithromycin
- telmisartan
- temazepam
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terazosin
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thiopental
- thioridazine
- thiotepa
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- tinidazole
- tipranavir
- tirzepatide
- tisotumab vedotin
- tivozanib
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolvaptan
- topiramate
- toremifene
- torsemide
- tovorafenib
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treprostinil
- tretinoin
- triamcinolone
- triamterene
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimethoprim
- trimipramine
- tripelennamine
- triprolidine
- tucatinib
U
V
- valbenazine
- valdecoxib
- valerian
- valproic acid
- valsartan
- vamorolone
- vandetanib
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
W
Z
Phenobarbital alcohol/food interactions
There are 2 alcohol/food interactions with phenobarbital.
Phenobarbital disease interactions
There are 15 disease interactions with phenobarbital which include:
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- cardiovascular
- prolonged hypotension
- renal dysfunction
- suicidal tendency
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
