Phenobarbital Drug Interactions
Currently displaying a list of 806 drugs known to interact with phenobarbital.
- 242 major drug interactions
- 517 moderate drug interactions
- 47 minor drug interactions
Medications known to interact with phenobarbital
Note: Showing generic names only.
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acebutolol
- acetaminophen
- acetylcarbromal
- acoramidis
- acrivastine
- adagrasib
- adalimumab
- afatinib
- albendazole
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- alpelisib
- alprazolam
- altretamine
- amiloride
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anagrelide
- anakinra
- anisindione
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- apremilast
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atogepant
- atorvastatin
- atrasentan
- avacopan
- avanafil
- avapritinib
- avatrombopag
- axitinib
- azatadine
- azelastine nasal
- azilsartan medoxomil
- baclofen
- bedaquiline
- belumosudil
- benazepril
- bendamustine
- bendroflumethiazide
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- betamethasone
- betaxolol
- betrixaban
- bexagliflozin
- bexarotene
- bimekizumab
- binimetinib
- biperiden
- bisoprolol
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
- cabazitaxel
- cabotegravir
- cabozantinib
- calcifediol
- calcitriol
- canagliflozin
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- capmatinib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carmustine
- carvedilol
- caspofungin
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorothiazide
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cholecalciferol
- cholestyramine
- cholic acid
- cimetidine
- citalopram
- clemastine
- clevidipine
- clindamycin
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cobimetinib
- cocaine nasal
- cocaine topical
- codeine
- colesevelam
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crinecerfont
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclophosphamide
- cyclosporine
- cyproheptadine
- dabigatran
- dabrafenib
- daclatasvir
- dantrolene
- daprodustat
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deflazacort
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- diclofenac
- dicumarol
- dienestrol topical
- difelikefalin
- digitoxin
- dihydroergotamine
- dihydrotachysterol
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- doravirine
- doxazosin
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drospirenone
- duloxetine
- duvelisib
- edoxaban
- efavirenz
- elacestrant
- elagolix
- eliglustat
- elranatamab
- elvitegravir
- emapalumab
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enfortumab vedotin
- ensartinib
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- eplerenone
- eprosartan
- eravacycline
- erdafitinib
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etonogestrel
- etoposide
- etravirine
- evening primrose
- everolimus
- exemestane
- ezogabine
- febuxostat
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- finerenone
- flavoxate
- flibanserin
- fluconazole
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- folic acid
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- fostemsavir
- fruquintinib
- furazolidone
- furosemide
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- ginkgo
- glasdegib
- glofitamab
- glycerol phenylbutyrate
- golimumab
- granisetron
- griseofulvin
- guanethidine
- guanfacine
- guselkumab
- halazepam
- haloperidol
- hemin
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydrocortisone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- ibrexafungerp
- ibrutinib
- idelalisib
- iloperidone
- imatinib
- imipramine
- indapamide
- indinavir
- indocyanine green
- infigratinib
- infliximab
- iptacopan
- irbesartan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isocarboxazid
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
- ixabepilone
- ixazomib
- l-methylfolate
- labetalol
- lacosamide
- lamotrigine
- landiolol
- lansoprazole
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- letrozole
- leucovorin
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levoleucovorin
- levomefolate calcium
- levomethadyl acetate
- levonorgestrel
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- linezolid
- liothyronine
- liotrix
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lomustine
- lonafarnib
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- lurbinectedin
- macimorelin
- macitentan
- maprotiline
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- mebendazole
- meclizine
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methimazole
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metronidazole
- metyrosine
- mibefradil
- midazolam
- midostaurin
- mifepristone
- minoxidil
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- momelotinib
- montelukast
- morphine
- morphine liposomal
- mosunetuzumab
- multivitamin, prenatal
- nabilone
- nadolol
- nalbuphine
- naldemedine
- naloxegol
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- neratinib
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
- norethindrone
- norgestrel
- nortriptyline
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- ospemifene
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxycodone
- oxymorphone
- ozanimod
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- paliperidone
- palovarotene
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paricalcitol
- paroxetine
- pazopanib
- pemigatinib
- pemoline
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimavanserin
- pimozide
- pindolol
- pioglitazone
- pirtobrutinib
- pitolisant
- polatuzumab vedotin
- polythiazide
- pomalidomide
- ponatinib
- ponesimod
- posaconazole
- pralsetinib
- pramipexole
- pramoxine topical
- praziquantel
- prazosin
- prednisolone
- prednisone
- pregabalin
- pretomanid
- prilocaine
- primidone
- procaine
- procaine penicillin
- procarbazine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- propafenone
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyridoxine
- pyrilamine
- raltegravir
- ramelteon
- ramipril
- ranolazine
- rasagiline
- regorafenib
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- revumenib
- ribociclib
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- risperidone
- ritlecitinib
- ritonavir
- rivaroxaban
- roflumilast
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
- sacituzumab govitecan
- safinamide
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- seladelpar
- selegiline
- selinexor
- selpercatinib
- selumetinib
- sertraline
- sibutramine
- sildenafil
- silodosin
- siltuximab
- silver nitrate topical
- silver sulfadiazine topical
- simeprevir
- siponimod
- sirolimus
- sirolimus protein-bound
- sodium nitrite
- sodium oxybate
- sodium phenylbutyrate
- sofosbuvir
- solifenacin
- sonidegib
- sorafenib
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfasalazine
- sunitinib
- suvorexant
- suzetrigine
- tacrolimus
- tadalafil
- talquetamab
- tamoxifen
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- teclistamab
- telaprevir
- telisotuzumab vedotin
- telithromycin
- telmisartan
- temazepam
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terazosin
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thiopental
- thioridazine
- thiotepa
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- tinidazole
- tipranavir
- tirzepatide
- tisotumab vedotin
- tivozanib
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolterodine
- tolvaptan
- topiramate
- toremifene
- torsemide
- tovorafenib
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treprostinil
- tretinoin
- triamcinolone
- triamterene
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimethoprim
- trimipramine
- tripelennamine
- triprolidine
- tucatinib
- valbenazine
- valdecoxib
- valerian
- valproic acid
- valsartan
- vamorolone
- vandetanib
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
Phenobarbital alcohol/food interactions
There are 2 alcohol/food interactions with phenobarbital.
Phenobarbital disease interactions
There are 15 disease interactions with phenobarbital which include:
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- cardiovascular
- prolonged hypotension
- renal dysfunction
- suicidal tendency
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
More about phenobarbital
- phenobarbital consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (36)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: barbiturate anticonvulsants
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Lamictal
Lamictal is an anti-epileptic medication used treat seizures in adults and children over 2 years ...
Carbamazepine
Carbamazepine is used to treat epileptic seizures and nerve pain such as trigeminal neuralgia ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Levetiracetam
Levetiracetam is used for bipolar disorder, epilepsy, hyperekplexia, neuralgia, new daily ...
Lyrica
Lyrica is used to control seizures, treat nerve pain and fibromyalgia. Learn about side effects ...
Topiramate
Learn about topiramate, an anticonvulsant used for seizures, migraine prevention, and weight loss ...
Diazepam
Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Learn ...
Lorazepam
Lorazepam is in a group of drugs called benzodiazepines and is used to treat anxiety disorders ...
Pregabalin
Pregabalin may be used to treat certain types of pain and used in combination with other ...
Lamotrigine
Lamotrigine is used for anxiety, bipolar disorder, borderline personality disorder, cyclothymic ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.