Diphenhydramine Interactions
There are 449 drugs known to interact with diphenhydramine, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 431 are moderate, and 3 are minor.
- View all 449 medications that may interact with diphenhydramine
- View diphenhydramine alcohol/food interactions (1)
- View diphenhydramine disease interactions (8)
Most frequently checked interactions
View interaction reports for diphenhydramine and the medicines listed below.
- Aspirin Low Strength (aspirin)
- Aspirin Low Strength (aspirin)
- CoQ10 (ubiquinone)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Succinate ER (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- MiraLAX (polyethylene glycol 3350)
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
- Zyrtec (cetirizine)
Diphenhydramine alcohol/food interactions
There is 1 alcohol/food interaction with diphenhydramine.
Diphenhydramine disease interactions
There are 8 disease interactions with diphenhydramine which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
Report options
More about diphenhydramine
- diphenhydramine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (544)
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: anticholinergic antiemetics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
