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Diphenhydramine Drug Interactions

Currently displaying a list of 448 drugs known to interact with diphenhydramine.

Return to the list of commonly checked interactions in combination with this medicine.

Medications known to interact with diphenhydramine

Note: Showing generic names only.

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Diphenhydramine alcohol/food interactions

There is 1 alcohol/food interaction with diphenhydramine.

Diphenhydramine disease interactions

There are 8 disease interactions with diphenhydramine which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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