Diphenhydramine Drug Interactions
Currently displaying a list of 449 drugs known to interact with diphenhydramine.
- 15 major drug interactions
- 431 moderate drug interactions
- 3 minor drug interactions
Medications known to interact with diphenhydramine
Note: Showing generic names only.
A
- abiraterone
- abobotulinumtoxinA
- acebutolol
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- alprazolam
- amantadine
- amiloride
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- atenolol
- atomoxetine
- atropine
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belladonna
- benazepril
- bendroflumethiazide
- benzgalantamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- biperiden
- bisoprolol
- bretylium
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- cetirizine
- cevimeline
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dacomitinib
- dantrolene
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- demecarium bromide ophthalmic
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- diltiazem
- dimenhydrinate
- disopyramide
- divalproex sodium
- dofetilide
- donepezil
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
E
- echothiophate iodide ophthalmic
- efavirenz
- eliglustat
- eluxadoline
- enalapril
- enalaprilat
- entacapone
- eplerenone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fesoterodine
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- givosiran
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- heroin
- histamine phosphate
- house dust mite allergen extract
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- hyoscyamine
I
- ibutilide
- ifosfamide
- iloperidone
- imipramine
- incobotulinumtoxinA
- indapamide
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- lemborexant
- letibotulinumtoxinA
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levorphanol
- lidocaine
- linezolid
- lisinopril
- lithium
- lofexidine
- loperamide
- lorazepam
- lorcaserin
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methscopolamine
- methsuximide
- methyldopa
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- mibefradil
- midazolam
- minoxidil
- mirabegron
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- nebivolol
- nefazodone
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- onabotulinumtoxinA
- opicapone
- opium
- oritavancin
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
P
- paliperidone
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pitolisant
- polythiazide
- porfimer
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pramipexole
- prazosin
- pregabalin
- primidone
- procainamide
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- prucalopride
- pyrilamine
Q
R
- ragweed pollen allergen extract
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- remifentanil
- remimazolam
- reserpine
- revefenacin
- rimabotulinumtoxinB
- risperidone
- rivastigmine
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- silodosin
- sodium iodide i-123
- sodium iodide-i-131
- sodium oxybate
- solifenacin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
T
- tacrine
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- timolol ophthalmic
- timothy grass pollen allergen extract
- tiotropium
- tirzepatide
- tizanidine
- tolcapone
- tolterodine
- topiramate
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
U
V
Z
Diphenhydramine alcohol/food interactions
There is 1 alcohol/food interaction with diphenhydramine.
Diphenhydramine disease interactions
There are 8 disease interactions with diphenhydramine which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
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- During pregnancy
- Support group
- Drug class: anticholinergic antiemetics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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