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Codeine Drug Interactions

A total of 865 drugs are known to interact with codeine.

  • 236 major drug interactions
  • 627 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with codeine.

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Type in a drug name to check for interactions with codeine.

Most frequently checked interactions

View interaction reports for codeine and the medicines listed below.

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Perfalgan, Arthritis Pain Relief, Efferalgan, Dafalgan, Tempra, Children's Tylenol, Doliprane, Paracetamol Teva, Feverall, Cetafen, Altenol, Cipla Genpharm Paracetamol, Paracetamol Almus, Lemsip Max, Paracetamol Ranbaxy, Infant's Tylenol, Tactinal, Panadol ActiFast, Promax, Tylenol 8 Hour, Lemsip Original, Panadol Soluble, Aceta, Pharbetol, Calpol Paediatric, Panadol Osteo, Mapap Arthritis Pain, Panadol Gel Tabs, Tylophen, Genapap, Pain Clear Paracetamol, Setamol, Blooms the Chemist Paracetamol, Capital Chemist Paracetamol, Acephen, Panadol Childrens, Buckley's Complete, Taminol, Efferalgan Pediatrique, Paracetamol Ivax, Actamin, BF-Paradac, Paracetamol Sandoz, Paracetamol Sandoz Conseil, Tycolene, Atasol, Acetaminophen-odan, Mapap Extra Strength Rapid Burst, Disprol Soluble Paracetamol, Calpol Fastmelts, Aminofen, Hedex, Valorin, Miradol, Parmol, Orajel Maximum Strength Toothache, Paraspen, RP Scherer Paracetamol, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Priceline Paracetamol, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Basics Paracetamol, Sigma Pain Relief, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Panadol Extend, Abenol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Little Fevers, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Panamol, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Q-Nol, Claradol, Anacin Aspirin Free, Conacetol, Dolono, Doliprane Adultes, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Pain-Eze, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Arrow, Paracetamol Biogaran, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Merck, Liquiprin, Paracetamol Qualimed, Adprin B, Paracetamol RPG, DG Health Pain Reliever, Tempra Quicklets, Lloydspharmacy Paracetamol Six Plus, Q-Pap, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Triaminic Infant Drops, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Mapap Rapid Tabs, Jr. Tylenol, Elixsure Fever/Pain, Infadrops, Calpol Infant, Disprol Paracetamol, Galpamol, Paldesic, Medinol Paediatric, Medinol Under 6, Alvedon, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, Anadin Paracetamol, UN-Aspirin Extra Strength, Mandanol, Actimol Children's, Dakota Paracetamol, Umphamol, Remedol, Panamax, Panamax 240, Paralgin, Parahexal, Febridol, Mid West Products Numol Paracetamol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Lemsip Childrens Cold & Flu, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Aleve (naproxen)
  • Aspirin Low Strength (aspirin)
  • Ativan (lorazepam)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Celebrex (celecoxib)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, Dry Cough, Robitussin CoughGels Long-Acting, Benylin DM, Bisolvon Dry, Hold DM, Calmylin, Pertussin CS Childrens, Delsym 12 Hour Cough Relief for Children & Adults, Vicks Formula 44, Strepsils Cough, Robafen Cough Liquidgels, Dexi-Tuss, Sucrets Cough, Creomulsion Children, Creomulsion, Tussin Cough Gels (Long Acting), Hold, DexAlone, Robitussin 12-Hour Cough Relief, St. Joseph Cough Suppressant, Vicks Dayquil Cough, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Nucosef DM, Strepsils Cough Relief, Delsym Children's 12-Hour Cough Relief, Buckleys Mixture, Pedia Relief, Triaminic Long Acting Cough, Buckley's DM, Buckley's Mixture Cough Suppressant, Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, ElixSure Cough, Scot-Tussin DM Cough Chasers, Robitussin Children's Cough Long-Acting, Pertussin ES, PediaCare Children's Long-Acting Cough, Tussin Pediatric, Robafen Pediatric Cough & Cold)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • guaifenesin (Mucinex, Robafen, Robitussin Chest Congestion, Tussin, Humibid, Guiatuss, Tussin Expectorant, Sorbutuss, Guaiatussin, Guaifenesin LA, Mucus Relief, Altarussin, Balminil Expectorant, Dristan Chesty Cough Guaiphenesin, Diabetic Tussin Mucus Relief, Mucinex Maximum Strength, Ganidin NR, Fenesin, Breonesin, Humavent LA, Lotussin, Diabetic Expectorant, Q-Tussin, Siltussin, Benylin E, Bidex-400, Humibid E, Buckley's Chest Congestion, Refenesen Chest Congestion Relief, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Iofen-NF, Humibid Pediatric, Organ-1 NR, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Muco-Fen LA, Liquibid, Muco-Fen 800, Scot-Tussin Expectorant, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Robitussin Mucus + Chest Congestion, Diabetic Tuss, Naldecon-EX Senior, Phanasin, Guaifenex G, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Xpect, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Mucinex for Kids, Guaifen NR, Liquituss GG, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Bronchoril, Hytuss, Organidin NR, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lyrica (pregabalin)
  • melatonin (Melatonin Time Release, SGard, Bio-Melatonin, Health Aid Melatonin, VesPro Melatonin)
  • Motrin (ibuprofen)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • Nexium (esomeprazole)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
  • OxyContin (oxycodone)
  • Paracetamol (acetaminophen)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • promethazine (Phenergan, Promethegan, Phenadoz, Phenoject-50, Anergan 50, Adgan, Phenazine 50, Phenergan Fortis, Antinaus 50, V-Gan-50, V-Gan-25, Pro-Med)
  • Seroquel (quetiapine)
  • Suboxone (buprenorphine / naloxone)
  • Symbicort (budesonide / formoterol)
  • Tylenol (acetaminophen)
  • Valium (diazepam)
  • Ventolin (albuterol)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Wellbutrin (bupropion)
  • Xanax (alprazolam)
  • Zoloft (sertraline)

Codeine alcohol/food interactions

There is 1 alcohol/food interaction with codeine

Codeine disease interactions

There are 16 disease interactions with codeine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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