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Matzim LA Dosage

Dosage form: tablet, extended release
Drug classes: Calcium channel blocking agents, Group IV antiarrhythmics

Medically reviewed by Last updated on Jan 19, 2023.

Take Matzim LA (diltiazem hydrochloride) extended-release tablets once a day at approximately the same time. Do not chew or crush the tablet.


Initiate dosing at 180 to 240 mg once daily, although some patients may respond to lower doses. Titrate according to blood pressure to a maximum of 540 mg daily. Maximum antihypertensive effect is usually observed by 14 days of chronic therapy.


Initiate dosing at 180 mg once daily and increase dose at intervals of 7 to 14 days if adequate response is not obtained, to a maximum of 360 mg.

Switching to Diltiazem Hydrochloride Extended-Release Tablets

Patients controlled on diltiazem alone or in combination with other medications may be switched to diltiazem hydrochloride extended-release tablets once-a-day at the nearest equivalent total daily dose. Higher doses of Matzim LA (diltiazem hydrochloride) extended-release tablets may be needed in some patients based on clinical response.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.