Ezetimibe Dosage
Medically reviewed by Drugs.com. Last updated on Jun 28, 2024.
Applies to the following strengths: 10 mg
Usual Adult Dose for:
- Hyperlipidemia
- Homozygous Familial Hypercholesterolemia
- Sitosterolemia
- Heterozygous Familial Hypercholesterolemia
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Hyperlipidemia
10 mg orally once a day
Uses:
- In combination with a statin, or as monotherapy when additional low-density lipoprotein cholesterol (LDL-C) lowering therapy is not possible, as an adjunct to diet for the reduction of elevated LDL-C in patients with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH)
- In combination with fenofibrate, as an adjunct to diet for the reduction of elevated LDL-C in patients with mixed hyperlipidemia
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in patients with homozygous familial hypercholesterolemia (HoFH)
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia
Usual Adult Dose for Homozygous Familial Hypercholesterolemia
10 mg orally once a day
Uses:
- In combination with a statin, or as monotherapy when additional low-density lipoprotein cholesterol (LDL-C) lowering therapy is not possible, as an adjunct to diet for the reduction of elevated LDL-C in patients with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH)
- In combination with fenofibrate, as an adjunct to diet for the reduction of elevated LDL-C in patients with mixed hyperlipidemia
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in patients with homozygous familial hypercholesterolemia (HoFH)
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia
Usual Adult Dose for Sitosterolemia
10 mg orally once a day
Uses:
- In combination with a statin, or as monotherapy when additional low-density lipoprotein cholesterol (LDL-C) lowering therapy is not possible, as an adjunct to diet for the reduction of elevated LDL-C in patients with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH)
- In combination with fenofibrate, as an adjunct to diet for the reduction of elevated LDL-C in patients with mixed hyperlipidemia
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in patients with homozygous familial hypercholesterolemia (HoFH)
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia
Usual Adult Dose for Heterozygous Familial Hypercholesterolemia
10 mg orally once a day
Uses:
- In combination with a statin, or as monotherapy when additional low-density lipoprotein cholesterol (LDL-C) lowering therapy is not possible, as an adjunct to diet for the reduction of elevated LDL-C in patients with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH)
- In combination with fenofibrate, as an adjunct to diet for the reduction of elevated LDL-C in patients with mixed hyperlipidemia
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in patients with homozygous familial hypercholesterolemia (HoFH)
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia
Usual Pediatric Dose for Homozygous Familial Hypercholesterolemia
Hetero- or Homozygous Familial Hypercholesterolemia:
- Age 10 years or older: 10 mg orally once a day
Homozygous Familial Sitosterolemia:
- Age 9 years or older: 10 mg orally once a day
Uses:
- In combination with a statin, as an adjunct to diet for the reduction of elevated LDL-C in pediatric patients 10 years of age and older with HeFH.
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in pediatric patients 10 years of age and older with HoFH
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in pediatric patients 9 years of age and older with homozygous familial sitosterolemia
Usual Pediatric Dose for Sitosterolemia
Hetero- or Homozygous Familial Hypercholesterolemia:
- Age 10 years or older: 10 mg orally once a day
Homozygous Familial Sitosterolemia:
- Age 9 years or older: 10 mg orally once a day
Uses:
- In combination with a statin, as an adjunct to diet for the reduction of elevated LDL-C in pediatric patients 10 years of age and older with HeFH.
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in pediatric patients 10 years of age and older with HoFH
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in pediatric patients 9 years of age and older with homozygous familial sitosterolemia
Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia
Hetero- or Homozygous Familial Hypercholesterolemia:
- Age 10 years or older: 10 mg orally once a day
Homozygous Familial Sitosterolemia:
- Age 9 years or older: 10 mg orally once a day
Uses:
- In combination with a statin, as an adjunct to diet for the reduction of elevated LDL-C in pediatric patients 10 years of age and older with HeFH.
- In combination with a statin, and other LDL-C lowering therapies, for the reduction of elevated LDL-C levels in pediatric patients 10 years of age and older with HoFH
- As an adjunct to diet, for the reduction of elevated sitosterol and campesterol levels in pediatric patients 9 years of age and older with homozygous familial sitosterolemia
Renal Dose Adjustments
Renal dysfunction: No adjustment recommended.
Liver Dose Adjustments
Mild liver dysfunction (Child-Pugh A): Data no available
Moderate or severe liver dysfunction (Child-Pugh B or C): Not recommended
Precautions
CONTRAINDICATIONS:
- Known hypersensitivity to the active component or to any of the ingredients
- In patients for whom a statin, fenofibrate, or other LDL-C lowering therapy are contraindicated, when this drug is used concomitantly with any of those agents; refer to the appropriate manufacturer product information for a list of contraindications
Safety and efficacy have not been established in:
- Patients less than 10 years of age with hetero- or homozygous familial hypercholesterolemia
- Patients less than 9 years of age with homozygous familial sitosterolemia
- Pediatric patients with other types of hyperlipidemia
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- For oral use
- May administer with or without food.
- Administer this drug at least 2 hours before or 4 hours after the administration of a bile acid sequestrant.
- If a dose is missed, take the missed dose as soon as possible. Do not double the next dose.
- Consult the appropriate manufacturer product information when using this drug concomitantly with another lipid-lowering therapy (e.g., statin).
Storage requirements:
- Store at room temperature between 68F to 77F (20C to 25C); protect from moisture.
Monitoring:
- Hepatic: Liver enzymes (as clinically indicated during therapy)
- Metabolic: LDL-C (as early as 4 weeks after initiating treatment and as clinically appropriate)
Patient advice:
- Read the US FDA-approved patient labeling (Patient Information).
- Understand that this drug may cause liver enzyme elevations.
- Promptly report any signs or symptoms of unexplained muscle pain, tenderness or weakness particularly if accompanied by malaise or fever to your health care provider.
- Tell your healthcare provider about all of the medicines you take, including over-the-counter products.
- Patients of childbearing potential: Notify your health care provider of a known/suspected pregnancy or if you are breastfeeding.
Frequently asked questions
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