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Amyl Nitrite Dosage

Applies to the following strengths: 0.3 mL

Usual Adult Dose for Angina Pectoris

1 to 6 inhalations of the vapor from a crushed ampule; may be repeated in 3 to 5 minutes if necessary.

Usual Adult Dose for Cyanide Poisoning

Inhalations of the vapor from a crushed ampule administered for up to 30 seconds every 2 minutes, using a fresh capsule each time until signs of recovery occur. Up to 8 capsules may be given if there is a delay in administering intravenous antidotes.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Amyl nitrite should be administered while the patient is sitting or lying down. A 0.3 mL ampule should be crushed between the fingers and held under the patient's nostrils. The patient should avoid rising abruptly following treatment due to the possibility of orthostasis.

When used for the treatment of angina, the patient should be advised to seek medical attention immediately if chest pain is not relieved after 2 doses.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.