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Amyl nitrite Side Effects

For the Consumer

Applies to amyl nitrite: inhalation solution

Along with its needed effects, amyl nitrite may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amyl nitrite:

Rare Signs and symptoms of overdose
  • Bluish-colored lips, fingernails, or palms of hands
  • dizziness (extreme) or fainting
  • feeling of extreme pressure in head
  • shortness of breath
  • unusual tiredness or weakness
  • weak and fast heartbeat

Some side effects of amyl nitrite may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fast pulse
  • flushing of face and neck
  • headache (mild)
  • nausea or vomiting
  • restlessness

For Healthcare Professionals

Applies to amyl nitrite: inhalation solution


Cardiovascular side effects manifesting as mild transitory headache, dizziness, and flushing of the face are common with the use of amyl nitrite. Hypotension, syncope, and tachycardia have also been reported.[Ref]

Nervous system

Nervous system side effects including cold sweats, pallor, restlessness, weakness, and involuntary passing of urine and feces have been reported.[Ref]


Gastrointestinal side effects including vomiting and nausea have been reported.[Ref]


Hematologic side effects including methemoglobinemia associated with high doses of chronically administered amyl nitrite have been reported.[Ref]


1. "Product Information. Amyl Nitrite (amyl nitrite)." Raway Pharmacal Inc, Accord, NY.

Some side effects of amyl nitrite may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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