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Amyl nitrite Side Effects

For the Consumer

Applies to amyl nitrite: inhalation solution

In addition to its needed effects, some unwanted effects may be caused by amyl nitrite. In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking amyl nitrite, check with your doctor or nurse as soon as possible:

  • Skin rash
  • unusual tiredness or weakness
Signs and symptoms of overdose
  • Bluish-colored lips, fingernails, or palms of hands
  • dizziness (extreme) or fainting
  • feeling of extreme pressure in head
  • shortness of breath
  • unusual tiredness or weakness
  • weak and fast heartbeat

Minor Side Effects

Some of the side effects that can occur with amyl nitrite may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fast pulse
  • flushing of face and neck
  • headache (mild)
  • nausea or vomiting
  • restlessness

For Healthcare Professionals

Applies to amyl nitrite: inhalation solution


Cardiovascular side effects manifesting as mild transitory headache, dizziness, and flushing of the face are common with the use of amyl nitrite. Hypotension, syncope, and tachycardia have also been reported.[Ref]

Nervous system

Nervous system side effects including cold sweats, pallor, restlessness, weakness, and involuntary passing of urine and feces have been reported.[Ref]


Gastrointestinal side effects including vomiting and nausea have been reported.[Ref]


Hematologic side effects including methemoglobinemia associated with high doses of chronically administered amyl nitrite have been reported.[Ref]


1. "Product Information. Amyl Nitrite (amyl nitrite)." Raway Pharmacal Inc, Accord, NY.

Not all side effects for amyl nitrite may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.