Amyl Nitrite Side Effects

Medically reviewed by Drugs.com. Last updated on May 14, 2025.

Applies to amyl nitrite: inhalation solution.

Precautions

Do not take sildenafil (e.g., Viagra) if you are taking this medicine. When sildenafil is taken with amyl nitrite, the combination can lower blood pressure and cause dizziness, lightheadedness, or fainting. In some cases, sildenafil taken with the related nitrates has caused death.

Amyl nitrite is extremely flammable. Keep it away from heat or any open flame, especially when crushing the capsule. Amyl nitrite can catch fire very easily and cause serious burns.

Dizziness or lightheadedness may occur, especially when you get up from a lying or sitting position. Getting up slowly may help, but if the problem continues or gets worse, check with your doctor.

Drinking alcohol while you are taking this medicine may make the dizziness or lightheadedness worse and may cause a serious drop in blood pressure. Check with your doctor before drinking alcoholic beverages.

After using a dose of amyl nitrite, you may get a mild headache that lasts for a short time. This is a common side effect and is no cause for alarm. However, if this effect continues, or if the headaches are severe, check with your doctor.

Common side effects of amyl nitrite

Some side effects of amyl nitrite may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of amyl nitrite

Along with its needed effects, amyl nitrite may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amyl nitrite:

Signs and symptoms of overdose

• bluish-colored lips, fingernails, or palms of hands
• dizziness (extreme) or fainting
• feeling of extreme pressure in head
• shortness of breath
• unusual tiredness or weakness
• weak and fast heartbeat

See also:

For healthcare professionals

Applies to amyl nitrite: inhalation solution.

Cardiovascular adverse events

Cardiovascular side effects manifesting as mild transitory headache, dizziness, and flushing of the face are common with the use of amyl nitrite. Hypotension, syncope, and tachycardia have also been reported.^[Ref]

Nervous system

Nervous system side effects including cold sweats, pallor, restlessness, weakness, and involuntary passing of urine and feces have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including vomiting and nausea have been reported.^[Ref]

Hematologic

Hematologic side effects including methemoglobinemia associated with high doses of chronically administered amyl nitrite have been reported.^[Ref]

Further information

Amyl nitrite side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer