Trelstar LA (triptorelin) Disease Interactions
There are 4 disease interactions with Trelstar LA (triptorelin):
GnRH agonists (applies to Trelstar LA) cardiovascular disease
Moderate Potential Hazard, Moderate plausibility.
Increased risk of developing myocardial infarction, sudden cardiac death and stroke has been reported in association with the use of GnRH agonists such as leuprolide, and triptorelin. Cardiovascular risk factors should be evaluated carefully before treatment initiation. Patients should be monitored for symptoms and signs suggestive of development or cardiovascular disease and should be managed according to current clinical practice.
GnRH agonists (applies to Trelstar LA) diabetes
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus
Hyperglycemia and an increased risk of developing diabetes have been reported in men receiving GnRH agonists such as leuprolide and triptorelin. Caution is advised in patients with diabetes as treatment with these agents may risk glycemic control. Monitor blood glucose and/or HbA1c periodically in patients receiving treatment.
Triptorelin (applies to Trelstar LA) QT prolongation
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Long QT Syndrome, Congestive Heart Failure, Electrolyte Abnormalities
Androgen deprivation therapy may prolong the QT/QTc interval. Health care providers should consider if benefits of therapy outweigh the potential risks in patients with congenital long QT syndrome, congestive heart failure, electrolyte abnormalities, or taking other drugs that can also prolong the QT interval. Consider periodic monitoring of EKG and electrolytes.
Triptorelin (applies to Trelstar LA) renal/liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease
Clinical trials with triptorelin showed that subjects with renal or liver impairment had 2- to 4-fold higher exposure (AUC values) than healthy men. Caution and monitoring of adverse events is recommended.
Trelstar LA (triptorelin) drug interactions
There are 261 drug interactions with Trelstar LA (triptorelin)
More about Trelstar LA (triptorelin)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- 1 Review
- Drug class: gonadotropin releasing hormones
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Drug Interaction Classification
|No interaction information available.|