Triptorelin Disease Interactions
There are 4 disease interactions with triptorelin:
GnRH agonists (Includes triptorelin) ↔ cardiovascular disease
Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease
Increased risk of developing myocardial infarction, sudden cardiac death and stroke has been reported in association with the use of GnRH agonists such as leuprolide, and triptorelin. Cardiovascular risk factors should be evaluated carefully before treatment initiation. Patients should be monitored for symptoms and signs suggestive of development or cardiovascular disease and should be managed according to current clinical practice.
GnRH agonists (Includes triptorelin) ↔ diabetes
Moderate Potential Hazard, Moderate plausibility. Applies to: Diabetes Mellitus
Hyperglycemia and an increased risk of developing diabetes have been reported in men receiving GnRH agonists such as leuprolide and triptorelin. Caution is advised in patients with diabetes as treatment with these agents may risk glycemic control. Monitor blood glucose and/or HbA1c periodically in patients receiving treatment.
Triptorelin (Includes triptorelin) ↔ QT prolongation
Moderate Potential Hazard, Moderate plausibility. Applies to: Long QT Syndrome, Congestive Heart Failure, Electrolyte Abnormalities
Androgen deprivation therapy may prolong the QT/QTc interval. Health care providers should consider if benefits of therapy outweigh the potential risks in patients with congenital long QT syndrome, congestive heart failure, electrolyte abnormalities, or taking other drugs that can also prolong the QT interval. Consider periodic monitoring of EKG and electrolytes.
Triptorelin (Includes triptorelin) ↔ renal/liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction, Liver Disease
Clinical trials with triptorelin showed that subjects with renal or liver impairment had 2- to 4-fold higher exposure (AUC values) than healthy men. Caution and monitoring of adverse events is recommended.
Triptorelin drug interactions
There are 350 drug interactions with triptorelin
More about triptorelin
- Triptorelin Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 5 Reviews
- Drug class: gonadotropin releasing hormones
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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