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Triptorelin Disease Interactions

There are 4 disease interactions with triptorelin.

Moderate

GnRH agonists (applies to triptorelin) cardiovascular disease

Moderate Potential Hazard, Moderate plausibility.

Increased risk of developing myocardial infarction, sudden cardiac death and stroke has been reported in association with the use of GnRH agonists such as leuprolide, and triptorelin. Cardiovascular risk factors should be evaluated carefully before treatment initiation. Patients should be monitored for symptoms and signs suggestive of development or cardiovascular disease and should be managed according to current clinical practice.

References

  1. (2002) "Product Information. Lupron (leuprolide)." TAP Pharmaceuticals Inc
  2. (2001) "Product Information. Trelstar (triptorelin)." Pharmacia and Upjohn
  3. (2002) "Product Information. Eligard (leuprolide)." Sanofi Winthrop Pharmaceuticals
Moderate

GnRH agonists (applies to triptorelin) diabetes

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

Hyperglycemia and an increased risk of developing diabetes have been reported in men receiving GnRH agonists such as leuprolide and triptorelin. Caution is advised in patients with diabetes as treatment with these agents may risk glycemic control. Monitor blood glucose and/or HbA1c periodically in patients receiving treatment.

References

  1. (2001) "Product Information. Trelstar (triptorelin)." Pharmacia and Upjohn
  2. (2002) "Product Information. Eligard (leuprolide)." Sanofi Winthrop Pharmaceuticals
Moderate

Triptorelin (applies to triptorelin) QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Long QT Syndrome, Congestive Heart Failure, Electrolyte Abnormalities

Androgen deprivation therapy may prolong the QT/QTc interval. Health care providers should consider if benefits of therapy outweigh the potential risks in patients with congenital long QT syndrome, congestive heart failure, electrolyte abnormalities, or taking other drugs that can also prolong the QT interval. Consider periodic monitoring of EKG and electrolytes.

References

  1. (2001) "Product Information. Trelstar (triptorelin)." Pharmacia and Upjohn
Moderate

Triptorelin (applies to triptorelin) renal/liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

Clinical trials with triptorelin showed that subjects with renal or liver impairment had 2- to 4-fold higher exposure (AUC values) than healthy men. Caution and monitoring of adverse events is recommended.

References

  1. (2001) "Product Information. Trelstar (triptorelin)." Pharmacia and Upjohn

Triptorelin drug interactions

There are 279 drug interactions with triptorelin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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