Skyrizi (risankizumab) Disease Interactions
There are 4 disease interactions with Skyrizi (risankizumab):
Risankizumab (applies to Skyrizi) hepatic/renal
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease
No specific studies have been conducted to determine the effect of renal or hepatic impairment on the pharmacokinetics of risankizumab. Caution is advised.
Risankizumab (applies to Skyrizi) infections
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral
Risankizumab may increase the risk of infections., and treatment with this medication should not be initiated in patients with any clinically important active infection until the infection resolves or is adequately treated. In patients with a chronic infection or a history of recurrent infection, consider the risks and benefits prior to prescribing risankizumab. Instruct patients to seek medical advice if signs or symptoms of clinically important infection occur. If a patient develops such an infection or is not responding to standard therapy, monitor the patient closely and do not administer risankizumab until the infection resolves.
Risankizumab (applies to Skyrizi) TB infection
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Tuberculosis -- Active, Tuberculosis -- Latent
Patients should be evaluated for tuberculosis (TB) infection prior to initiating treatment with risankizumab. Consider anti-TB therapy prior to initiating treatment in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after risankizumab treatment. Do not administer this medication to patients with active TB.
Risankizumab (applies to Skyrizi) vaccinations
Moderate Potential Hazard, Moderate plausibility.
Prior to initiating therapy with risankizumab, consider completion of all age appropriate immunizations according to current immunization guidelines. Avoid use of live vaccines in patients treated with risankizumab. No data are available on the response to live or inactive vaccines.
Skyrizi (risankizumab) drug interactions
There are 121 drug interactions with Skyrizi (risankizumab)
More about Skyrizi (risankizumab)
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- Drug class: interleukin inhibitors
- FDA Approval History
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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