Plecanatide Disease Interactions
There are 2 disease interactions with plecanatide.
Plecanatide (applies to plecanatide) dehydration
Major Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities
Plecanatide should be used with caution in dehydrated patients and patients with severe diarrhea. Plecanatide is contraindicated in patients less than 6 years of age as these patients may be more likely to develop severe diarrhea and its potentially serious consequences. Care is recommended when using this agent in adult patients with electrolyte abnormalities or with severe diarrhea. It is recommended to suspend dosing and rehydrate the patient if such symptoms occur during therapy.
Plecanatide (applies to plecanatide) gastrointestinal obstruction
Major Potential Hazard, Moderate plausibility.
The use of plecanatide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.
Plecanatide drug interactions
There is 1 drug interaction with plecanatide.
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- Drug class: guanylate cyclase-C agonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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