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Metaxalone Disease Interactions

There are 3 disease interactions with metaxalone.

Major

Metaxalone (applies to metaxalone) anemia

Major Potential Hazard, Moderate plausibility.

The use of metaxalone is contraindicated in patients with or predisposed to drug-induced, hemolytic, or other anemias. Rare incidences of hemolytic anemia have been associated with the administration of metaxalone.

References

  1. (2024) "Product Information. Skelaxin (metaxalone)." King Pharmaceuticals, Inc.
Major

Metaxalone (applies to metaxalone) renal/liver disease

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

The use of metaxalone is contraindicated in patients with severe hepatic and/or renal dysfunction. Metaxalone is metabolized by the liver and subsequently eliminated by the kidney, thus both parent drug and metabolites may accumulate in such patients. Therapy with metaxalone should be administered cautiously in patients with mild to moderate hepatic and/or renal impairment.

References

  1. (2024) "Product Information. Skelaxin (metaxalone)." King Pharmaceuticals, Inc.
Moderate

Metaxalone (applies to metaxalone) alcohol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Alcoholism

Metaxalone has central nervous system (CNS) depressant effects and should be used with caution with other CNS depressants including alcohol.

References

  1. (2024) "Product Information. Skelaxin (metaxalone)." King Pharmaceuticals, Inc.

Metaxalone drug interactions

There are 313 drug interactions with metaxalone.

Metaxalone alcohol/food interactions

There is 1 alcohol/food interaction with metaxalone.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.