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Metaxalone: 6 things you should know

Medically reviewed by C. Fookes, BPharm Last updated on Dec 5, 2018.

1. How it works

  • Metaxalone relaxes muscles. The exact way it works has not been established; however, experts suggest it suppresses brain activity which results in sedation, reducing the sensation of pain.
  • Metaxalone does not directly relax tense skeletal muscles.
  • Metaxalone belongs to the class of medicines known as muscle relaxants.

2. Upsides

  • May be used to relieve pain and stiffness associated with certain muscle conditions, sprains, or strains.
  • Should be used in conjunction with rest and physical therapy.
  • Generic metaxalone is available.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Drowsiness, dizziness, headache, and irritability. Nausea, vomiting, abdominal discomfort, anemia, rash, and jaundice have also been reported. Rarely, anaphylaxis (a severe allergic reaction) may occur.
  • Both food and age affect the absorption of metaxalone. At a younger age (approximately 25 years), taking metaxalone with food almost doubles its maximum concentration. As people get progressively older, absorption of metaxalone both with and without food increases.
  • Should not be taken by people with anemia (either drug-induced, hemolytic, or other).
  • May not be suitable for people with liver or kidney disease. Liver function monitoring may be necessary for some patients with pre-existing liver disease if the benefits of taking metaxalone are thought to outweigh the risks.
  • May enhance the effect of alcohol and other CNS depressants.
  • May interact with other drugs including opioids, cough medicines, antidepressants, and benzodiazepines.
  • Needs to be taken three to four times daily.
  • Should not be used in children under 12.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

4. Bottom Line

Metaxalone is a muscle relaxant that appears to exert its effects through sedation.

5. Tips

  • Take metaxalone as directed by your doctor. Swallow the tablets whole with a glass of water. Do not take more metaxalone than prescribed.
  • Taking metaxalone with food can increase its absorption and enhance its effects (such as sedation). Elderly people may be more susceptible.
  • Metaxalone causes sedation and you should not drive, operate machinery, or perform other hazardous tasks while taking this medication. Avoid alcohol.
  • May cause false-positive Benedict's tests (a test used to detect the presence of glucose in the urine).
  • Talk to your doctor if you have any worrying side effects such as shortness of breath, a rash, or feel unusually weak or tired.
  • Talk to a doctor or pharmacist before taking any other medications with metaxalone, including those bought over-the-counter, to check that they are compatible with metaxalone.

6. Response and Effectiveness

Peak plasma concentrations of metaxalone occur within three hours of an oral dose.


Metaxalone [Package Insert]. Revised 10/2018. Rising Pharmaceuticals, Inc.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use metaxalone only for the indication prescribed.

Copyright 1996-2019 Revision date: December 5, 2018.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.