Amitiza (lubiprostone) Disease Interactions
There are 4 disease interactions with Amitiza (lubiprostone):
Lubiprostone (Includes Amitiza) ↔ GI obstruction
Severe Potential Hazard, Moderate plausibility. Applies to: Gastrointestinal Obstruction
Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.
Lubiprostone (Includes Amitiza) ↔ diarrhea
Moderate Potential Hazard, Moderate plausibility. Applies to: Diarrhea, Electrolyte Abnormalities
Lubiprostone should not be prescribed to patients that have severe diarrhea. Care should be exercised when prescribing this drug to patients at risk of diarrhea and patients should be instructed to inform their physician if severe diarrhea occurs.
Lubiprostone (Includes Amitiza) ↔ dyspnea
Moderate Potential Hazard, Moderate plausibility. Applies to: Pulmonary Impairment
The use of lubiprostone may cause dyspnea. Care should be taken when prescribing this drug to patients that experienced dyspnea or when restarting the drug in those patients experiencing drug induced dyspnea.
Lubiprostone (Includes Amitiza) ↔ hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
No dosage adjustment is needed in patients with mild hepatic impairment. It is recommended to modify the dose in patients with moderate and severe hepatic impairment as these patients experienced markedly higher systemic drug exposure that can cause an increased incidence and severity of adverse events.
Amitiza (lubiprostone) drug interactions
There is 1 drug interaction with Amitiza (lubiprostone)
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- Drug class: chloride channel activators
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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