Amitiza Disease Interactions
There are 4 disease interactions with Amitiza (lubiprostone).
Lubiprostone (applies to Amitiza) GI obstruction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction
Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.
Lubiprostone (applies to Amitiza) diarrhea
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities
Lubiprostone should not be prescribed to patients that have severe diarrhea. Care should be exercised when prescribing this drug to patients at risk of diarrhea and patients should be instructed to inform their physician if severe diarrhea occurs.
Lubiprostone (applies to Amitiza) dyspnea
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Impairment
The use of lubiprostone may cause dyspnea. Care should be taken when prescribing this drug to patients that experienced dyspnea or when restarting the drug in those patients experiencing drug induced dyspnea.
Lubiprostone (applies to Amitiza) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No dosage adjustment is needed in patients with mild hepatic impairment. It is recommended to modify the dose in patients with moderate and severe hepatic impairment as these patients experienced markedly higher systemic drug exposure that can cause an increased incidence and severity of adverse events.
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Amitiza drug interactions
There is 1 drug interaction with Amitiza (lubiprostone).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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