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Loratadine Disease Interactions

There is 1 disease interaction with loratadine.

Moderate

Loratadine (applies to loratadine) renal/liver disease

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.

References (6)
  1. Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N (1990) "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol, 30, p. 364-71
  2. Clissold SP, Sorkin EM, Goa KL (1989) "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs, 37, p. 42-57
  3. Hilbert J, Moritzen V, Parks A, Radwanski E, Perentesis G, Symchowicz S, Zampaglione N (1988) "The pharmacokinetics of loratadine in normal geriatric volunteers." J Int Med Res, 16, p. 50-60
  4. (2002) "Product Information. Claritin (loratadine)." Schering Corporation
  5. Schiano TD, Bellary SV, Cassidy MJ, Thomas RM, Black M (1996) "Subfulminant liver failure and severe hepatotoxicity caused by loratadine use." Ann Intern Med, 125, p. 738-40
  6. Monroe EW (1996) "Safety and efficacy of loratadine in urticaria." Int J Dermatol, 35, p. 837-41

Switch to consumer interaction data

Loratadine drug interactions

There are 111 drug interactions with loratadine.

Loratadine alcohol/food interactions

There is 1 alcohol/food interaction with loratadine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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