Linaclotide Disease Interactions
There are 2 disease interactions with linaclotide.
Linaclotide (applies to linaclotide) gastrointestinal obstruction
Major Potential Hazard, High plausibility.
The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.
References (1)
- (2012) "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals
Linaclotide (applies to linaclotide) diarrhea
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities, Hypokalemia, Hyponatremia
The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.
References (1)
- (2012) "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals
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Linaclotide drug interactions
There are 59 drug interactions with linaclotide.
Linaclotide alcohol/food interactions
There is 1 alcohol/food interaction with linaclotide.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
